Training in Oncology Population Sciences (TOPS)

项目摘要/摘要 肿瘤学人口科学(TOPS)T32计划将培训博士后研究员进行 在T3和T4界面进行研究，将实验室中的知识转化为实践，并将人口健康转化为 减轻癌症负担。在T3和T4界面进行翻译研究的需要源于 在癌症结果方面的持续差异和在以下背景下可能的执行差距 临床试验和常规实践中发生的事情。TOPS项目将每人培养3名博士后研究员 年，与达纳-法伯/哈佛癌症中心7个机构的36名教职员工合作。 培训将为研究员提供必要的技能，以应对带来的挑战和机遇。 关于癌症护理、精准医疗、电子健康的复杂性的巨大增长 病历、移动健康、机器学习和数据共享。TOPS计划有3个具体的战略来 实现这一总体目标：1)通过以下途径培训调查所需的核心方法和技能 课业和参加定期的研讨会、研讨会和阅读；2)集中精力进行研究 在一个或多个导师的密切监督下进行项目；以及，3)培训专业技能 调查的先决条件，包括项目开发、赠款编写、演示、建造和工作 拥有不同的团队，运营干燥实验室，负责任地进行研究。 TOPS T32提案是成功的R25CA092203癌症结果研究计划的更新 培训(PCORT)，2002年至2017年培训了41名博士后和博士后研究员。托普斯将联合- 由初级保健医生南希·基廷博士和内科肿瘤学家黛博拉·施拉格博士领导，两人都 在PCORT指导委员会任职的专注于癌症的杰出人口科学家和 培训了许多已经成为独立研究人员的研究员。TOPS打算培养博士后 具有医学、护理、行为科学、药学、经济学、临床等专业学位的学生 致力于癌症重点人群的流行病学、卫生政策、信息学和工程学 科学。该计划的核心是一个由36名教师导师和13名新兴导师组成的小组，他们具有以下专业知识 质量测量、患者、临床医生、社区和卫生系统级干预措施的设计、实施 实用试验、比较有效性研究、调查分析、行政和电子健康 记录数据以及优化实施的组织和行为战略方面的专业知识。在最后 在为期两年的培训中，TOPS计划的参与者将具备启动所需的技能 在以癌症为重点的人口科学领域从事独立研究，并可获得 DF/CC和哈佛大学的翻译研究培训催化剂计划。TOPS联合导演和 由8名成员组成的指导委员会提供支持，该委员会包括7个机构中每一个机构的领导人 DF/HCC的成员和6名在人口科学方面有成就的研究人员将担任顾问。

PROJECT SUMMARY/ABSTRACT The Training in Oncology Population Sciences (TOPS) T32 program will train postdoctoral fellows to conduct research at the T3 and T4 interface to translate knowledge from the lab into practice and population health to reduce the burden of cancer. The need for translational research at the T3 and T4 interface stems from persistent disparities in cancer outcomes and implementation gaps between what is possible in the context of clinical trials and what happens in routine practice. The TOPS program will train 3 postdoctoral fellows each year in collaboration with 36 faculty from across the 7 institutions of the Dana-Farber/Harvard Cancer Center. Training will provide fellows with the skills necessary to address the challenges and opportunities brought about by the tremendous growth in the complexity of cancer care, precision medicine, electronic health records, mobile health, machine learning and data sharing. The TOPS program has 3 specific strategies to achieve this overarching objective: 1) training in core methods and skills necessary for investigation through coursework and participation in regular seminars, workshops and reading; 2) intensive focus on a research project with close supervision from one or more mentors; and, 3) training in professional skills that are prerequisite for investigation including project development, grant writing, presentation, building and working with diverse teams, running a dry-laboratory and the responsible conduct of research. The TOPS T32 proposal is a renewal of the successful R25CA092203 Program in Cancer Outcomes Research Training (PCORT), which trained 41 pre- and post-doctoral fellows between 2002 and 2017. TOPS will be co- led by Dr. Nancy Keating, a primary care physician, and Dr. Deborah Schrag, a medical oncologist, both accomplished cancer-focused population scientists who served on the PCORT Steering Committee and trained numerous fellows who have become independent researchers. TOPS intends to train postdoctoral students with degrees in the fields of medicine, nursing, behavioral science, pharmacy, economics, clinical epidemiology, health policy, informatics, and engineering for careers dedicated to cancer-focused population science. The core of the program is a group of 36 faculty mentors and 13 emerging mentors with expertise in quality measurement, design of patient, clinician, community and health system-level interventions, conduct of pragmatic trials, comparative effectiveness research, analysis of survey, administrative and electronic health record data, and expertise in organizational and behavioral strategies that optimize implementation. At the end of the two-year training, TOPS program participants will be well-equipped with the skills necessary to launch independent research careers in cancer-focused population science and have access to the core resources of the DF/HCC and the Harvard Catalyst program for translational research training. The TOPS co-directors and are supported by an 8-member Steering Committee that includes leaders from each of the 7 institutional members of the DF/HCC and 6 accomplished investigators in population science who will serve as Advisors.