SBIR Phase I- Topic 410 - Cancer Clinical Trials Recruitment and Retention Tools for Participant Engagement.

许多临床试验未能达到其应计和保留目标，这导致了延迟， 提前终止，或在审判结束时因损失 统计学上的力量。NCI希望通过以下方式加强临床试验的招募和保留 开发工具，以加强参与者和研究人员之间的沟通。 在此阶段1工具开发应用程序中，我们将解决NCI对简化 知情同意文件，以加强知情期间的个人沟通 同意程序。在这个第一阶段的提案中，我们利用自然语言处理技术和我们的 团队先前在知情同意本体(ICO)方面的工作，以改进中的语言 与研究参与者授予的许可特别相关的同意文件。

Many clinical trials fail to meet their accrual and retention goals, which leads to delays, early termination, or inability to draw conclusions at trial completion due to loss of statistical power. NCI wants to enhance clinical trials recruitment and retention by developing tools that could enhance communication between participants and study staff. In this Phase 1 tool development application we address the NCI interest in simplified informed consent documents that enhance personal communication during the informed consent process. In this Phase I proposal we leverage natural language processing technology and our teams prior work on the Informed Consent Ontology (ICO) to improve the language in consent documents related specifically to permissions granted by a research participant.