Quantifying the Cardiovascular and Immunologic Changes after Spinal Cord Injury to Aid Diagnosis of Clinically Meaningful Infections

7.项目总结/摘要 尿路感染（UTI，包括导管相关UTI）始终是前三位原因之一 用于脊髓损伤（SCI）患者的医疗保健，每年的费用超过20亿美元，更不用说 这种情况对生活质量的重大影响。虽然认识和对待真正的 尿路感染是明显的，区别于无症状菌尿（ASB，阳性尿培养 没有感染的临床体征或症状）在SCI后特别具有挑战性，因为 感觉UTI诊断中最常见的体征和症状。这往往导致主观 患者和SCI提供者对UTI体征和症状的解释。膀胱器械， SCI后通常需要留置或间歇性导尿以安全地排尿， 然而，维持抗生素水平会导致不需要治疗的ASB的高发生率。不适当 用抗生素治疗ASB导致多药耐药生物体的发展，这些生物体的耐药性更高， 与年龄和合并症相匹配的队列相比，SCI患者的发病率和死亡率较高。 这个难题的一个可能的解决方案是SCI后UTI的诊断支持工具;以前成功的工具 测量多个生理变量的异常程度，以测量急性疾病的严重程度。 然而，为了计算异常程度，我们必须更好地了解生命体征的正常值。 SCI患者人群的体征测量和常见实验室研究。因此，这一目标 研究的目的是：1）建立慢性SCI与基线生命体征和实验室测量之间的联系 通过利用国家退伍军人健康管理局（VHA）数据源的病例对照研究; 2） 确定一系列生理变量的阳性预测值，定义为筛选工具 SCI后严重UTI的患者。从这项研究中获得的数据将支持 NIH R 01提案旨在外部验证和评估严重UTI筛查工具的性能 前瞻性地。组装的研究团队和环境非常适合完成这项工作， 得到当地和全国临床、研究、行政和患者倡导领导层的支持。 该项目支持NICHD/NCMRR优先确定和治疗与癌症相关的继发性疾病。 残疾人。

7. Project Summary/Abstract Urinary tract infection (UTI, including catheter-associated UTI), is consistently amongst the top three reasons for health care use for persons with spinal cord injury (SCI), with a yearly cost of over $2 billion, not to mention the significant impact of the condition on quality of life. While the importance of recognizing and treating true UTI is evident, distinguishing this condition from asymptomatic bacteriuria (ASB, a positive urine culture without clinical signs or symptoms of infection) is particularly challenging after SCI due to the impaired ability to sense the most common signs and symptoms used in UTI diagnosis. This often leads to subjective interpretations of UTI signs and symptoms by patients and SCI providers alike. Bladder instrumentation with either indwelling or intermittent catheterization is often necessary after SCI to safely eliminate urine and maintain continence, however leads to high rates of ASB that do not need to be treated. Inappropriate treatment of ASB with antibiotics leads to the development of multi-drug resistant organisms, which are higher in persons with SCI than their age and co-morbidity-matched cohorts, conveying high morbidity and mortality. A possible solution to this conundrum is a diagnostic support tool for UTI after SCI; previously successful tools measure the degree of abnormality of multiple physiologic variables to measure the severity of acute disease. To calculate the degree of abnormality, however, we must have a better sense of the normal values for vital sign measurements and common laboratory studies for the SCI patient population. Therefore, the aims of this study are to 1) Establish the association between chronic SCI and baseline vital sign and lab measurements through a case-control study utilizing national Veterans Health Administration (VHA) data sources; and 2) Determine the positive predictive value of a constellation of physiologic variables defined as a screening tool for severe UTI after SCI through a retrospective cohort study. The data obtained from this study will support a NIH R01 proposal aimed to externally validate and assess the performance of the severe UTI screening tool prospectively. The assembled study team and environment are uniquely suited to completing this work, and have the support of clinical, research, administrative and patient advocacy leadership locally and nationally. This project supports the NICHD/NCMRR priority of identifying and treating secondary conditions associated with disability.