California National Primate Research Center

项目摘要 位于加州大学戴维斯分校的加州国家灵长类动物研究中心（CNPRC）是 在未来五年（2018年5月1日至2019年5月30日）的基础运营拨款#P51-OD 011107的支持下， 2023年4月30日）。CNPRC的战略重点是多学科研究团队， 开发和使用人类健康和疾病的非人类灵长类动物模型。目前，在第58届 CNPRC在全国范围内为NIH支持的一系列研究人员提供服务。从创始到 今年，CNPRC通过提供高质量的 动物、设施、工具和服务，由核心科学家的知识基础设施驱动， 用非人类灵长类动物进行基础和转化研究。CNPRC的目标反映在 （1）进行最先进的研究，并在科学上为 用不同年龄段的非人灵长类动物模型理解和治疗人类疾病，（2） 为当地、区域和国家的研究人员提供卓越的非人灵长类动物专业知识和服务。 国家层面，以推进NIH支持的卓越研究，（3）指导和培训下一代 具有非人类灵长类专业知识的翻译研究人员，以及（4）确保最高标准的 负责任地进行研究和动物护理。下一个供资期的计划将以专门知识为基础， 生产力和创新;与东道国机构和国家计划的紧密联系;最大限度地提高 用于NIH资助的研究。 加州国家灵长类动物研究中心（CNPRC）正在提交一份改建和装修 关于艾滋病研究中高度优先主题的行政补编的建议。本申请 将用于传染病/SIV手术室和手术准备室的设施翻新。 CNPRC在Koen VanRompay博士的领导下有一个强大的传染病项目。主要重点 是SIV模型，在治疗、疫苗开发和艾滋病毒合并症方面进行了积极的研究， 感染的病人。 拟议项目是购买和安装暖通空调设备。成本增加导致 原合同中未提供的设备。还包括购买设备的资金， 手术室 所要求的这笔资金将完成这一翻新工程，并通过提供以下服务来加强CNPRC的艾滋病毒/艾滋病研究： 1.一个无菌生存手术套件，专门用于NIH资助的研究人员进行艾滋病毒/艾滋病研究 2.相邻的手术准备和手术室，用于小手术、内窥镜检查和 SIV感染动物的CSF采样 3.新的支持空间，在SIV感染动物中进行肺功能测试，作为 HIV/AIDS共病的跨学科研究

PROJECT SUMMARY The California National Primate Research Center (CNPRC), located at the University of California, Davis, is supported by the base operating grant #P51-OD011107 for the next five year period (May 1, 2018 through April 30, 2023). The CNPRC has a strategic emphasis on multidisciplinary research teams that focus on the development and use of nonhuman primate models of human health and disease. Currently in the 58th year of operation, the CNPRC serves a range of NIH-supported investigators nationwide. From inception through the current year, the CNPRC has been highly responsive to the research community by providing high quality animals, facilities, tools, and services driven by the intellectual infrastructure of the Core Scientists that guide and conduct basic and translational research with nonhuman primates. The goals for the CNPRC are reflected in the following Specific Aims: (1) Conduct state-of-the-art research and scientifically contribute to the understanding and treatment of human disease with nonhuman primate models across the age spectrum, (2) Provide exceptional nonhuman primate expertise and services to investigators at the local, regional, and national levels to advance NIH-supported research excellence, (3) Mentor and train the next generation of translational investigators with nonhuman primate expertise, and (4) Ensure the highest standards of responsible conduct of research and animal care. Plans for the next funding period build upon expertise, productivity, and innovation; strong ties with the host institution and national programs; and maximizing resources for NIH-funded research. The California National Primate Research Center (CNPRC) is submitting an Alterations and Renovations proposal for the Administrative Supplements related to high priority topics in AIDS research. This application will be for facility renovation for an Infectious Disease/SIV Surgery Suite and Surgery Preparation Room. The CNPRC has a strong program in Infectious Disease led by Dr. Koen VanRompay. The major emphasis of is the SIV model with active research in therapeutics, vaccine development, and co-morbidities of HIV- infected patients. The proposed project is for the purchase and installation of HVAC equipment. Cost increases resulted in this equipment not being supported by the original award. Funds are also included for purchase of equipment for the surgical suite. This funds requested will complete this renovation will enhance HIV/AIDs research at the CNPRC by providing 1. A sterile survival surgery suite dedicated to NIH funded investigators conducting HIV/AIDs research 2. An adjacent surgery preparation and procedure room for minor surgical procedures, endoscopy, and CSF sampling in SIV infected animals 3. New support space to conduct pulmonary function testing in SIV infected animals as part of interdisciplinary studies in HIV/AIDs co-morbities