P&F program

试点和可行性补助计划 摘要 波士顿地区糖尿病和内分泌学研究中心试点和可行性(BADERC P&F)计划 在招聘和保持糖尿病和内分泌学研究方面的新人才方面一直很有效，而且在 在糖尿病研究领域具有新想法的现有研究人员中培养最具创新性的试点项目。 我们2000-2014年前三个资助周期的P&F受助人随后的资助历史是 出色，尽管资金环境不利，近75%的调查人员实现了后续PI 与糖尿病相关的NIH或基金会拨款状况，绝大多数仍在学术领域 与糖尿病相关的研究。73个试点奖项是在最近10年的全额、积极资助期间管理的， 仅(2009-2019年)就产生了87笔NIH R级项目赠款(或同等数额)，估计超过 9300万美元的研究资金。因此，2009-2019年管理的大约390万美元的P&F基金的投资 实现了2200%的投资回报，不包括额外的NIH职业发展奖和额外的 基金会和行业基金。在这73名获奖者中，令人印象深刻的77%的人后来患上了糖尿病- 相关研究经费，91%仍在学术糖尿病研究中。更刻意的进化 该计划一直致力于资助越来越多的尖端临床和转化研究 项目，占2014-2019年供资周期所有供资申请的三分之一以上。在我们两年的资助期间 GAP，证明了我们对这一有影响力的计划和培养下一代领导人的承诺 糖尿病研究，我们继续支持7个最具创新性的P&F提案，并在第二年 资助，并资助2个新的BADERC-哈佛营养肥胖研究中心(NORC-H)共同资助 通过明智的资金重新分配提出建议。总体而言，BADERC P&F项目的成功反映了 组成BADERC研究基地的研究人员招募和培训优秀、雄心勃勃、 富有创造力和多产的年轻调查人员。BADERC P&F项目对职业生涯的贡献是显而易见的 这些令人兴奋的年轻科学家的进展和他们进入糖尿病研究。这个节目有终极的 培养那些将对促进知识和治疗学进步做出贡献的人的职业生涯的目标 各种形式的糖尿病。在即将到来的赠款期间，我们将继续资助和支持最有前途的P&F 项目，并引入创新，促进BADERC招募和留住最有才华和 波士顿地区基础、临床和转化性糖尿病相关的不同研究人员 研究。

PILOT and FEASIBILITY GRANT PROGRAM SUMMARY The Boston Area Diabetes and Endocrinology Research Center Pilot and Feasibility (BADERC P&F) program has been effective both in recruiting and maintaining new talent in diabetes and endocrinology research, and in fostering the most innovative pilot projects among established investigators with a new idea in diabetes research. The subsequent funding history of P&F recipients from our first three funding cycles 2000-2014 has been outstanding, despite the adverse funding climate, with nearly 75% of investigators achieving subsequent PI status on diabetes-related NIH or foundation grants, and the overwhelming majority remaining in academic diabetes-related research. The 73 pilot awards administered over the most recent 10 years of full, active funding, alone (2009-2019) have spawned 87 NIH R-level project grants (or equivalent), estimated at more than $93,000,000 in research funding. As such, the investment of ~$3.9M of P&F funds administered 2009-2019 has realized a >2200% return on investment, exclusive of additional NIH career development awards, and additional foundation and industry funding. Of these 73 awardees, an impressive 77% have obtained subsequent diabetes- related research funding, and 91% remain in academic diabetes research. A further deliberate evolution of the program has been towards funding an increasing number of cutting-edge clinical and translational research projects, comprising over 1/3 of all funded applications in the 2014-2019 funding cycle. During our 2-year funding gap, a testament to our commitment to this impactful program and to growing the next generation of leaders in diabetes research, we have continued to support 7 of the most innovative P&F proposals with a second year of funding, and funded 2 new BADERC-Nutrition Obesity Research Center of Harvard (NORC-H) jointly funded proposals by judicious funding reallocation. Overall, the success of the BADERC P&F program reflects the ability of the investigators who constitute the BADERC research base to recruit and train outstanding, ambitious, creative and productive young investigators. The BADERC P&F program contributes demonstrably to the career progress of these exciting young scientists and their entry into diabetes research. The program has the ultimate goal of fostering the careers of those who will contribute to the advancement of knowledge and therapeutics for all forms of diabetes. In the coming grant period, we will continue to fund and support the most promising P&F projects, and introduce innovations that further the BADERC mission to recruit and retain the most talented and diverse pool of investigators throughout the Boston area in basic, clinical, and translational diabetes-related research.