Developing research leaders at the intersection of malnutrition and tuberculosis in Tanzania

项目总结/摘要 这是一个新的全球传染病研究培训计划（GIDRTP）在大学的申请， 弗吉尼亚州（弗吉尼亚大学）通过以下方式扩展了数十年来在贫困疾病和传染病方面培训全球领导人的工作： 新出现传染病国际培训和研究支助周期， 能力，少数民族健康国际研究培训和福格蒂GIDRTPs。这些先前的经历 提供经验教训和经过检验的机制，将受训人员培养成独立的公共卫生人员 科学家尽管先前的重点是早期阶段的学员，如本科生，硕士或博士生， 我们注意到坦桑尼亚博士后培训在研究领导力方面存在独特的障碍。 我们在2021年对坦桑尼亚博士后科学家进行了需求评估，证实了这一点 观察和概述的差距和机会，以构建一个博士后为重点的GIDRTP。UVA， 传染病和国际卫生部以及全球卫生公平中心一直在 几十年来，在营养不良及其传染性后果的研究和培训方面处于最前沿。在非- 在大流行时期，结核病（TB）是可治愈的传染病的主要杀手。COVID-19进一步 结核病治疗中断，预计在未来五年内结核病死亡人数将增加20%。营养不良， 营养不足和营养不良导致糖尿病等疾病，是最重要的驱动因素， 结核病在全球范围内因此，本项目旨在加强现有的教育和研究联系 弗吉尼亚大学和基利曼哈罗基督教医科大学学院/基利曼哈罗临床研究所 （KCMUCo/KCRI）在坦桑尼亚，以支持坦桑尼亚博士后学员成长为研究领导者， 处于营养不良和结核病的交叉点。 我们的目标是培养6名博士后科学家，每人通过个性化研究提供3年的支持 领导力计划基于非洲研究领导力报告（2020年）的框架。此外 匹配博士后研究员坦桑尼亚和UVA导师，个性化的研究领导计划将 包括由首席教育工作者和核心计划教师（包括生物统计学家）进行评估， 个性化的课程和技能建设对研究团队管理的指标类别， 沟通，赠款写作，专业精神和职业轨迹。我们将利用现有的基础设施 美国国立卫生研究院、比尔和梅林达·盖茨基金会、欧洲和发展中国家 国家试验伙伴关系、世界卫生组织和丹麦外交部结核病和 坦桑尼亚的营养不良研究，我们希望启动初级科学家和内容领导者的职业生涯 他们将竞争独立的资金，制定研究议程，制定政策，并使他们的社区受益- 符合世界卫生组织的终结结核病战略。

PROJECT SUMMARY / ABSTRACT This application for a new Global Infectious Diseases Research Training program (GIDRTP) at the University of Virginia (UVA) extends decades of training global leaders in diseases of poverty and infectious diseases through cycles of support of International Training and Research in Emerging Infectious Diseases, Actions for Building Capacity, Minority Health International Research Training, and Fogarty GIDRTPs. These prior experiences provide lessons learned and tested mechanisms for developing trainees into independent public health scientists. Despite the prior focus on early stage trainees such as undergraduate, Masters or doctoral students, we have noted unique barriers in progression through postdoctoral training to research leadership in Tanzania. We performed a needs assessment among Tanzanian postdoctoral scientists in 2021 which confirmed this observation and outlined gaps and opportunities with which to structure a postdoctoral focused GIDRTP. UVA, the Division of Infectious Diseases and International Health, and the Center for Global Health Equity have been at the forefront of research and training in malnutrition and its infectious consequences for decades. In non- pandemic periods, tuberculosis (TB) is the leading killer from a curable infectious disease. COVID-19 has further disrupted TB care and is projected to increase deaths from TB by 20% over the next five years. Malnutrition, both undernutrition and poor nutrition leading to conditions such as diabetes mellitus, is the most important driver of TB disease globally. Therefore, this GIDRTP aims to strengthen existing educational and research linkages with the UVA and the Kilimanjaro Christian Medical University College/ Kilimanjaro Clinical Research Institute (KCMUCo/KCRI) in Tanzania, to support Tanzanian postdoctoral trainees' growth to research leaders working at the intersection of malnutrition and TB. We aim to train 6 postdoctoral scientists with 3 years of support each through an individualized research leadership plan based on the framework of the Path to Research Leadership in Africa Report (2020). In addition to matching postdoctoral fellows to Tanzanian and UVA mentors, the individualized research leadership plan will include assessment by Lead Educators and core programmatic faculty including a biostatistician to design personalized coursework and skills building toward the metric categories of research team management, communication, grant writing, professionalism and career trajectory. We will harness the current infrastructure of funding from the National Institutes of Health, Bill and Melinda Gates Foundation, European and Developing Countries Trials Partnership, World Health Organization and the Danish Ministry of Foreign Affairs for TB and malnutrition research in Tanzania, and we expect to launch the careers of junior scientists and content leaders that will compete for independent funding, set research agendas, make policy and benefit their communities in- line with the World Health Organization's End TB Strategy.