Alternating Current Electrolysis for Organic Synthesis

项目摘要 随着对环境和可持续性的日益关注， 将绿色化学和绿色工程整合到制药行业的需求。 电化学有机合成代表了传统有机合成的绿色和有利的替代方案， 因为它直接使用来自电源的电子来完成氧化还原 转型，这可以减少化学品的使用，减少浪费，并提供 成本、安全性和可持续性的改善。然而，目前的反应库 电合成方法是有限的。因此，迫切需要新的电解方法 提供新的化学反应性。 该提案的重点是研究大多未开发的交流电解， 有机合成与使用常数的常规电有机合成方法不同， 电压或电流，交流电解使用交流电压来驱动氧化还原 底物的转化。交流电电解提供了一种独特的反应 两个氧化还原相反的反应可以在空间和时间上彼此接近的环境 并且可以通过仅控制交流电压源而容易地调节。 该提案的总体目标是利用这种独特的交替反应环境， 目前的电解，以实现新的反应，目前无法获得现有的 合成方法，作为实现电气的长期愿景的关键一步， 推动药物的绿色合成。

PROJECT SUMMARY With growing concerns regarding the environment and sustainability, there is an increasing demand for integrating green chemistry and green engineering into the pharmaceutical industry. Electrochemical organic synthesis represents a green and advantageous alternative to traditional synthetic methods because it directly uses electrons from a power source to complete the redox transformations, which can cut down on the usage of chemicals, reduce waste, and offer improvements in cost, safety, and sustainability. However, the current reaction library of electrosynthetic methods is limited. Therefore, there is a critical need for new electrolytic methods that offer new chemical reactivities. The proposal is focused on studying the mostly unexplored alternating current electrolysis for organic synthesis. Unlike the conventional electroorganic synthetic methods using a constant voltage or current, alternating current electrolysis uses an alternating voltage to drive the redox transformations of substrates. Alternating current electrolysis offers a unique reaction environment where two redox-opposite reactions can occur spatially and temporally close to each other and can be easily adjustable by merely controlling the alternating current voltage supply. The overall goal of this proposal is to exploit this unique reaction environment of alternating current electrolysis to achieve new reactivities that are not currently accessible by the existing synthetic methodologies, serving as a critical step towards the long-term vision of the electrically driven green synthesis of drugs.