Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission

摘要/摘要 总括 内华达州是受到限制研究影响的24个机构发展奖(IDEA)州之一 容量。我们的生物医学研究卓越中心(Cobre)的首要目标是 神经退行性变和翻译神经科学(CNTN)是建立翻译神经科学研究的基础 基础设施，开发创新的诊断方法和治疗干预措施，可以 适用于神经退行性疾病(NDD)和不同人群。CNTN具有重要意义 对于国家代表来说，考虑到由于持续增加而即将需要与年龄相关的新城疫医疗保健 在内华达州人口中，包括退休人员。 我们具有主题凝聚力的多学科团队包括来自克利夫兰诊所的调查人员 拉斯维加斯鲁沃脑健康中心(LRCBH)和内华达大学拉斯维加斯分校(UNLV)。在.期间 Cobre支持的头五年，CNTN改变了翻译神经科学的环境 在内华达州南部的研究。CNTN第一阶段的主要成果是：1-脑成像的创建 LRCBH致力于研究工作的部门；2--建立一个包括NDD的研究队列 具有深刻表型特征的科目；3--建立数据管理和统计核心；4-- 脑健康系成立，其创始主席是CNTN初级调查员(JI)；5-The 成立社区咨询委员会，协助开展社区外展活动，目的是邀请不同的 个人自愿参与临床研究项目；以及6--研究人员临界数量的增加。一个 一批有前途的JIS利用CNTN汇编的资源进行了高度创新 研究项目。所有的联合调查组都从CNTN计划毕业，独立资助和推广 在本地或外部的高水平机构内。我们的评估单位创造了新的评估方法 基于团队科学的方法来评估每个CNTN核心和JI的表现。 他们证明，增加科学网络的规模会导致科学产品的膨胀。 在第二阶段，国家技术网络打算开发实现可持续性所需的资源和进程。为 为此，我们正在修改CNTN领导层，以应对日益增长的责任。由以下机构编制的评估报告 我们的评估股将被用来制定我们的战略，监测进展情况，并做出最终的调整。 具体来说，我们计划促进基础设施建设，加强CNTN的事业发展 研究人员，启动试点项目计划，并刺激研究生产力。我们期待着我们的努力 将导致与学术和行业合作伙伴的新合作，这将使CNTN走上 可持续发展。

SUMMARY/ABSTRACT Overall Nevada (NV) is one of the 24 Institutional Development Award (IDeA) states affected by restricted research capacity. The overarching goal of our Center of Biomedical Research Excellence (COBRE) Center for Neurodegeneration and Translational Neuroscience (CNTN) is to establish translational neuroscience research infrastructure in Southern NV to develop innovative diagnostic methods and therapeutic interventions that can be applied across neurodegenerative disorders (NDD) and in diverse populations. The CNTN is highly significant for State representatives given the upcoming needs of age-related NDD healthcare due to the sustained increase in the population of NV, including retirees. Our thematically cohesive, multidisciplinary team comprises investigators from both the Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas (LRCBH), and the University of Nevada Las Vegas (UNLV). During the first five years of COBRE support, the CNTN has transformed the environment for translational neuroscience research in Southern NV. The main accomplishments of CNTN Phase 1 are: 1- the creation of a Brain Imaging Department at LRCBH dedicated to research endeavors; 2- the building of a research cohort comprising NDD subjects who are deeply phenotyped; 3- the establishment of a Data Management and Statistics Core; 4- the inauguration of a Department of Brain Health, whose Founding Chair was a CNTN Junior Investigator (JI); 5- the forming of a Community Advisory Board to assist with community outreach activities aimed at inviting diverse individuals to volunteer in clinical research projects; and 6- the increase in the critical mass of investigators. A promising group of JIs have leveraged the resources compiled by the CNTN to carry out highly innovative research projects. All the JIs have graduated from the CNTN program with independent funding and promotion within local or external high caliber institutions. Our Assessment Unit has created new assessment methods based on a Science of Team Science approach to assess the performance of each individual CNTN Core and JI. They demonstrated that increasing the size of a scientific networking results in the inflation of scientific products. In Phase 2, the CNTN intends to develop the resources and processes necessary to reach sustainability. For this, we are revising the CNTN leadership to tackle growing responsibilities. The evaluation reports produced by our Assessment Unit will be utilized to elaborate our strategy, monitor progress, and make eventual adjustments. Specifically, we plan to foster infrastructure development, strengthen the career development of CNTN investigators, launch a pilot project program, and stimulate research productivity. We anticipate that our efforts will result in new collaborations with academic and industry partners, which will put the CNTN on the path for sustainability.