Developmental Core

摘要-JHU TRAC开发核心(DC) 发展核心(DC)的使命是支持和指导下一代结核病研究人员 并招募新的结核病调查人员，以增加约翰霍普金斯大学结核病科学家的多样性和广度 大学(JHU)。早期调查人员(ESI)需要将各种学科整合到他们的工作中，并且 其他领域的创新领导者需要被纳入结核病研究领域，以产生变革性的成果 在基础和临床研究、翻译和实施方面。尽管工作效率和成就 JHU教职员工，培养和维持一批新的调查人员(NI)，他们可以提供领导和 未来的创新极具挑战性。如果没有专门的资源来支持NI和ESI，许多 受训人员会转移到其他领域。人们认识到需要种子资金、核心资源和密集的 为新的研究人员提供指导，他们也将受益于在初级培训之外扩大的技能集。 DC将寻求从代表性不足的科学和科学家领域中吸取教训，包括 未来的研究/培训。结核病方面缺乏系统生物学等领域；因此，我们将寻求引入 计算模型师、生物信息学家和免疫学家来填补这一空白。新的方法可以 需要了解结核病的发病机制，这对分子诊断、治疗性疫苗、 和宿主指导的疗法。护理模式，以增加预防、获得治疗、保留和人类- 以坚持为中心的模式以及感染控制和预防科学是公认的领域 结核病外来者。最后，利益攸关方参与以社区为基础的参与性研究方法是 在全球结核病控制方面日益需要。 JHU TRAC DC的总体目标是支持最优先的创新、跨学科结核病 研究，在团队科学方面支持和指导ESI，并招募和支持结核病的NI。发展奖 由疾病控制中心提供，将为ESI和目前未参与结核病研究的知名调查人员提供 有机会激发创新想法，并获得对富有成效的跨学科新领域的支持， 合作研究。区议会将特别关注调查人员的招聘和职业发展。 在与健康相关的研究(UHRR)中，全国代表性不足。除了发展中的 奖励，发展核心将通过对赠款的内部科学审查来加强个人指导 提案，包括具体目标审查；TRAC特定写作责任小组(WAGs)，TRAC K- 支持K01、K08、K23或K99应用程序开发的俱乐部，以及供调查人员使用的TRAC K2R俱乐部 从K奖励过渡到R01奖励。发展核心将与行政核心合作，以 通过每周一次TRAC系列研讨会促进思想和方法的交流，正在进行的研究 会议、研讨会和一年一度的JHU结核病科学会议和TRAC数据交易会。

ABSTRACT – JHU TRAC DEVELOPMENTAL CORE (DC) The mission of the Developmental Core (DC) is to support and mentor the next generation of TB researchers and to recruit new TB investigators to increase the diversity and breadth of TB scientists at Johns Hopkins University (JHU). Early Stage Investigators (ESI) need to integrate a variety of disciplines into their work, and innovative leaders in other fields need to be brought into the TB research fold to generate transformational gains in basic and clinical research, translation, and implementation. Despite the productivity and accomplishments of the JHU faculty, nurturing and sustaining a pipeline of New Investigators (NI) who can provide leadership and innovation in the future is extremely challenging. Without dedicated resources to support NI and ESI, many trainees move onto other fields. There is a recognized need for seed funding, core resources, and intensive mentoring for new researchers, who also would benefit from broadened skill sets beyond their primary training. The DC will seek to draw from areas of underrepresented science and scientists, including opportunities for future research/training. Fields such as systems biology in TB are lacking; thus, we will seek to bring in computational modelers, bioinformaticians, and immunologists to fill this void. Novel approaches to understanding TB pathogenesis are needed, with implications for molecular diagnostics, therapeutic vaccines, and host-directed therapies. Nursing models to increase prevention, access to treatment, retention and human- centered adherence models, as well as infection control and prevention science are recognized areas needing TB outsiders. Finally, engagement of stakeholders in community-based participatory research methods is increasingly needed in TB control globally. The overall goals of the JHU TRAC DC are to support the highest priority innovative, cross-disciplinary TB research, to support and mentor ESI in team science, and to recruit and support NI to TB. Developmental Awards provided by the DC will provide both ESI and established investigators not currently involved in TB research with the opportunity to stimulate innovative ideas and to receive support for fruitful new areas of interdisciplinary, collaborative research. A special focus of the DC will be the recruitment and career development of Investigators among groups nationally underrepresented in health-related research (UHRR). In addition to the Developmental Awards, the Developmental Core will augment individual mentorship with Internal Scientific Reviews of grant proposals, including specific aims reviews; TRAC-specific Writing Accountability Groups (WAGs), a TRAC K- Club to support development of K01, K08, K23, or K99 applications, and a TRAC K2R Club for investigators transitioning from K awards to R01 grants. The Developmental Core will work with the Administrative Core to facilitate exchange of ideas and methodologies through a weekly TRAC Seminar Series, research-in-progress meetings, workshops, and the annual JHU TB Scientific Meeting and TRAC Data Fair.