Core C: Data

抽象--数据核心 数据核心的主要用途是收集、存储、协调和传输所有数据、元数据和 在U19中心(拦截疼痛中心)内生成的分析策略到U24 DCIC和 救治站台。数据核心将进行多种跨学科的基因组和统计分析，以研究 以及整合从三个单独的组成部分项目获得的多水平组学数据 拦截中心。拦截中心项目涉及广泛的数据管理和复杂 分析。这样的分析需要有组织地同时考虑来自不同组件的数据 项目，并需要稳健和创新的综合分析方法。数据核心提供了 所需的数据管理和协调职能，以及生物信息学专门知识和创新 整合基因组分析，使拦截中心取得成功。数据的主要目的是 核心是作为实验设计改进、数据质量控制、 管理、集成、分析和解释，并充当促进数据和 拦截中心各个项目和核心之间的信息交流和协作。已建成 基于核心成员在多组学数据方面的密切而长期的合作和丰富的经验 分析认为，该数据核心将通过以下具体目标提供基本服务：1)提供中央 为U19中心内的所有研究人员提供数据存储、管理和信息安全服务 确保及时向Hear平台提交数据和数据分析。2)一体化多体 识别空间分辨的细胞、基因和通路的外周神经系统的特征 与疼痛状况有关。

Abstract – Data Core The primary purpose of the Data core is to collect, store, coordinate, and transfer all data, metadata, and analysis strategies generated within the U19 center (the INTERCEPT pain center) to the U24 DCIC and the HEAL Platform. The Data core will conduct multiple inter-disciplinary genomic and statistical analyses to study and integrate the multi-level omics data obtained from the three individual component projects of the INTERCEPT Center. The INTERCEPT Center projects involve extensive data management and complex analyses. Such analyses require organized and simultaneous consideration of data from different component projects, and demand robust and innovative integrated analysis methodology. The Data core provides the required data management and coordination function, as well as the bioinformatic expertise and innovative integrated genomic analysis to enable the success of the INTERCEPT Center. The main objective of the Data core is to serve as a backbone support resource for experimental design refinement, data quality control, management, integration, analyses, and interpretation, and serve as a central hub to foster data and information exchange and collaboration between individual projects and cores in the INTERCEPT Center. Built upon the Core members’ close and long-time collaboration and extensive experience in multi-omics data analyses, this Data core will provide essential services through the following specific aims: 1) Provide central data storage, management, and information security services to all researchers within the U19 Center and ensure the timely submission of data and data analyses to the HEAL Platform. 2) Integrated multi-omic characterization of the peripheral nervous system to identify spatially resolved cells, genes, and pathways associated with pain conditions.