A prospective multiethnic HFpEF cohort from California's Central Valley

摘要 这是一份申请，要求为NIH U 01提供行政补充，以增强多样性 HL 160274授权。拟议的临床和生物信息学研究相结合，虽然在范围内， 父母补助金，不属于资助的具体目标。候选人的长期目标是追求职业生涯， 一个专注于为服务不足的社区服务的医生科学家。本补充旨在获得新的 关于血液学因素如何与射血分数保留性心力衰竭（HFpEF）风险相关的见解 通过建立在现有的目标，从母奖的因素。具体而言，拟议的研究旨在利用 在西班牙裔患者中观察到的糖尿病、高血压和肥胖的患病率增加， 相应的经济因素-包括气候，环境，饮食和生活方式，医疗干预， 身体形态、身体活动和炎症--用它们的生物学标记物测试HFpEF。 相关的社会环境决定因素。通过了解经济因素的贡献，我们将 深入了解针对患者的治疗，以改善其长期健康结果。候选人及 导师已经制定了全面的培训目标，并组建了一支强大的导师团队，以确保 候选人将获得宝贵的技术培训，研究经验和职业发展。 因此，这一拟议的补编将为候选人提供一个职业发展的平台， 与此同时，通过减少科学研究工作队伍中代表性不足的现象来促进多样性， 在FOA（PA-18-906）中。从拟议补编中获得的新见解将高度补充和 在家长补助金中加强项目。

ABSTRACT This is an application requesting for an Administrative Supplement to Enhance Diversity for the NIH U01 HL160274 grant. The proposed combined clinical and bioinformatics studies, although within the scope of the parent grant, are not in the funded Specific Aims. The long-term goal of the candidate is to pursue a career as a physician-scientist with a focus on servicing underserved communities. This supplement aims to obtain new insights on how exposomic factors correlate to heart failure with preserved ejection fraction (HFpEF) risk factors by building upon the existing aims from the parent award. Specifically, the proposed study aims to use the increased prevalence of diabetes, hypertension, and obesity observed in Hispanic patients, and their corresponding exposomic factors – including climate, environment, diet and lifestyle, medical interventions, body morphology, physical activity, and inflammation – to test the biological markers of HFpEF with their associated socioenvironmental determinants. By understanding the exposomic factor contributions, we will gain insights into patient-specific treatment to improve their long-term health outcomes. The candidate and the mentors have outlined a comprehensive training goal and have assembled a strong Mentoring Team to ensure that the candidate will receive valuable technical training, research experience, and career development. Therefore, this proposed supplement will provide the candidate a platform for career development while, in parallel, fostering diversity by reducing underrepresentation in the workforce of scientific research, as outlined in the FOA (PA-18-906). New insights obtained from the proposed supplement will highly complement and enhance the project in the parent grant.