Cancer Epidemiology and Population Science

项目总结/摘要 癌症流行病学和人口科学（CEPS）研究计划主要集中在癌症， 爱荷华州，霍尔顿综合癌症中心（HCCC）集水区，同时认识到，其影响， 远远超出了国家。CEPS的主要目标是进行基于人口的研究， 提高我们对癌症病因、发病率和死亡率的理解，以探索干预措施， 降低癌症发病率和死亡率，提高癌症幸存者的生活质量。来实现这一点 通过三个相关的研究目标集中在1）癌症病因学，2）原发性和继发性癌症 预防和3）癌症保健服务和成果。最近有影响力的CEPS出版物 治疗淋巴瘤、慢性淋巴细胞白血病、对侧乳腺癌、胰腺癌和乳腺癌 生存、压力和生命终结问题，以及美国预防服务工作队 癌症预防和筛查的建议。CEPS成员包括28名正式成员和9名准成员 成员横跨五所学院的十七个学系。同行评审研究的年度直接资助总额 在上一个预算年度为430万美元，其中150万美元来自NCI。CEPS成员的生产力很高， 自2016年以来，撰写或合著了372篇与癌症相关的同行评议出版物， 协作，24%（n=91）为计划内，18%（n=70）为计划间，63%（n=235） 机构间出版物。其中52篇出版物发表在高影响力期刊（影响因子）上 >10）。成功的项目内/项目间和多机构合作正在产生重要的癌症- 农药和多氯联苯接触知识的相关进展;淋巴瘤，肉瘤， 乳腺癌、卵巢癌和结肠直肠癌; HPV相关的癌症和疫苗接种;多发病科学; 癌症筛查和戒烟。

PROJECT SUMMARY/ABSTRACT The Cancer Epidemiology and Population Science (CEPS) research program focuses primarily on cancer in Iowa, the Holden Comprehensive Cancer Center (HCCC) catchment area, while recognizing that its impact extends well beyond the state. The primary goal of the CEPS is to conduct population-based research that improves our understanding of cancer etiology, morbidity, and mortality in order to explore interventions for reducing cancer incidence and mortality and improving quality of life for cancer survivors. This is accomplished through three related research aims centered on 1) cancer etiology, 2) primary and secondary cancer prevention and 3) cancer health care services and outcomes. Recent influential CEPS publications have addressed lymphoma, chronic lymphocytic leukemia, contralateral breast cancer, pancreatic and breast cancer survival, stress, and end-of-life issues, as well as United States Preventive Services Task Force recommendations for cancer prevention and screening. CEPS membership includes 28 full and nine associate members spanning 17 departments across five colleges. Annual total direct funding for peer-reviewed research in the last budget year was $4.3 million with $1.5 million from the NCI. CEPS members are highly productive, having authored or co-authored 372 cancer-related peer-reviewed publications since 2016, and highly collaborative, with 24% (n=91) intraprogrammatic, 18% (n=70) interprogrammatic, and 63% (n=235) interinstitutional publications. Fifty-two of these publications appeared in high impact journals (Impact Factor >10). Successful intra/interprogrammatic and multi-institutional collaborations are generating important cancer- related advances in knowledge about pesticide and polychlorinated biphenyl exposures; lymphoma, sarcoma, and cancers of the breast, ovary, and colorectum; HPV-related cancer and vaccination; multimorbidity science; cancer screening; and tobacco cessation.