2022 SoCal Genome Stability Symposium

摘要 2022年SoCal基因组稳定性研讨会是一个为期一天的会议，将在加州大学举行。 加州，欧文。近年来，许多新的癌症治疗方法已被开发为靶向DNA修复 途径。这些新疗法目前正在从实验室走向临床，我们正准备快速 扩展新的DNA修复途径靶向药物，将用于消除不同类型的癌症。 会议将重点讨论基因组不稳定性，DNA诱变，环境诱变剂， DNA损伤信号，DNA修复机制，以及它们在癌症和治疗中的意义。在 来自南加州实验室的研究生和博士后研究员 致力于这些特定主题的工作将展示他们目前未发表的研究。各项目的和目标 会议的目的是：1）促进南加州实验室之间的互动 致力于这些特定的主题。会议期间的互动将促进新的 来自不同研究机构的不同实验室之间的合作。2)为了让学生和 博士后研究员到一个快速发展的研究领域的新前沿。学员将接触到 该领域最新的研究方法。3)促进青年科学家建立网络的机会 并通过多样化的网络和与其他人的互动来获得正式和非正式的职业发展 在该领域的PI，可能打开未来的博士后或教师职位的机会。4)提供一种 为参加研讨会的学员营造包容和严谨的氛围。研讨会将 加强来自所有性别，背景和起源的学生和博士后研究员之间的互动， 包括历史上被边缘化的身份，如代表性不足的种族和族裔群体， 残疾人，不同性取向的人， 社会经济背景不利。通过地方一级的培训， 像这样的会议对于培训学员为下一个职业阶段做好准备特别重要， 博士后研究员或主要研究者。

ABSTRACT The 2022 SoCal Genome Stability Symposium is a one-day conference that will be held at the University of California, Irvine. In recent years, many novel cancer therapies have been developed to target DNA repair pathways. These new therapies are currently moving from the lab to the clinic, and we are poised for a rapid expansion of new DNA repair pathway-targeting drugs that will be used to eliminate different types of cancer. The conference will focus on research on genomic instability, DNA mutagenesis, environmental mutagens, DNA damage signaling, mechanisms of DNA repair, and their implications in cancers and therapies. At the conference, graduate students and postdoctoral fellows from laboratories located in Southern California working on these specific topics will present their current unpublished research. The goals and objectives of the conference are: 1) To stimulate the interactions among laboratories across Southern California working on these specific topics. The interactions during the meeting will promote the emergence of new collaborations between different laboratories from different research institutions. 2) To expose students and postdoctoral fellows to new frontiers of a rapidly progressing research area. The trainees will be exposed to the newest research approaches in the field. 3) To catalyze opportunities for young scientists to network and to gain formal and informal career development by diversifying their networks and interacting with other PIs in the field, potentially opening future postdoctoral or faculty position opportunities. 4) To provide an atmosphere of inclusion and rigor for the trainees participating in the symposium. The symposium will enhance interactions among students and postdoctoral fellows from all genders, backgrounds, and origins, including historically marginalized identities such as those from underrepresented racial and ethnic groups, individuals with disabilities, individuals with different sexual orientations, and individuals from socioeconomically disadvantaged backgrounds. Broader awareness of the field gained through local meetings such as this is particularly important to preparing trainees for their next career stages as postdoctoral fellows or as principal investigators.