Tuskegee University Health Disparities Biomedical Research Center

Over view-Carver研究基金会附件-基因组学和健康差距研究中心 (CGHDR) 我们寻求NIH的支持，在现有的历史悠久的卡弗研究大楼的基础上建造一座附属建筑，以定位我们的尖端癌症 基因组学研究，专注于翻译计算生物学研究。新增加的将容纳 塔斯基吉大学从事计算和湿实验室基因组学研究的许多生物医学研究人员日益增长的需求 研究和我们即将雇用的许多研究人员。因此，这一添加将提供一致的现代基础设施 满足当前生物医学研究和多样化劳动力培训的复杂要求。 健康差异是塔斯基吉大学生物医学研究的一个焦点和区别点，塔斯基吉大学是塔斯基吉大学的一个 正在涌现的卓越。与健康差距相关的疾病是美国发病率和死亡率的主要原因 在当前的新冠肺炎大流行中，这些国家和地区是非常令人痛心的例证。非洲裔美国人继续受苦 不成比例地受到这些疾病和其他慢性疾病的影响，包括肥胖症和糖尿病--都受到个人的影响 遗传易感性以及环境和生活方式因素，包括饮食、营养和体力活动。塔斯基吉 大学位于阿拉巴马州的黑带(这个术语最初指的是该地区的黑色表土，现在更多的是指它的 主要是非洲裔美国人)。塔斯基吉市和黑带是印度最贫穷的地区之一 美国 我们寻求成为全球知名的癌症基因组学新兴卓越中心，专注于健康差异。 在过去的几年里，我们的癌症研究努力越来越集中在基因组学、转录组学、 计算生物学和数字病理学，获得了大量赠款，并在影响较大的期刊上发表了文章。 然而，我们现有的实验室基础设施在一栋老化的建筑中已经严重不足，无法支持这些 现代研究的努力。此外，我们最近还获得了享有盛誉的美国国立卫生研究院合作第一奖 与UAB合作，这将要求我们招聘12名新的终身教职轨道教师，其中3名住在塔斯基吉。这些新的 教职员工将对复杂的实验室基础设施提出更多要求，而这些基础设施是我们现有设施所不具备的。 塔斯基吉大学的生物医学研究中心目前位于历史悠久的卡弗研究基金会。它 支持多个互补的研究项目，包括少数民族机构研究中心(RCMI)和 莫尔豪斯医学院/塔斯基吉大学/阿拉巴马大学伯明翰分校(UAB)综合 解决癌症健康公平的伙伴关系(CPACHE)。综合生物科学博士项目(IBS)是独一无二的 准备探索阿拉巴马州黑带内未得到充分服务的人群的基因组图谱。总体而言，这些计划 促进生物医学研究，促进将基础研究转化为创新的新疗法和行为 以缩小阿拉巴马州黑带地区和东南部地区的健康差距。 卡弗研究大楼的新附属设施将是塔斯基吉大学校园内的第一个专门用于 生物医学研究和研究生教育。CGHDR将由大约8,000平方英尺的绿色/可持续新 建造的空间将容纳潮湿的实验室工作台；生物信息学/基因组核心研究工作区；教职员工办公室， 为这些研究人员提供支持的实习生、研究生和管理人员；以及会议室。情结的意志 包括开放实验室形式，将支持五个新实验室和三个核心实验室(显微镜、生物信息学、 和基因组学/蛋白质组学/分子生物学)。研究大楼将是世界上第一座通过LEED认证的建筑 塔斯基吉大学校园，也是黑带地区为数不多的校园之一。拟建的中心将提供一个地点来识别 塔斯基吉预防和治疗疾病的新战略和提高所有生物医学研究人员的能力 大学。新中心无疑将为阿拉巴马州黑带缩小健康差距的研究做出贡献 地区和更远的地区。该中心还将为校园内的其他几个研究小组提供有价值的基础设施， 包括农业基因组学和天然产物研究，工程学院的纳米靶向药物输送， 和传染病，肉类和家禽安全，以及兽医学院内的病原体。此外， 新大楼还将帮助我们吸引和留住高素质的科学人才，这是塔斯基吉农村地区的一个长期挑战 布景。

OVER VIEW - Carver Research Foundation Annex – Center for Genomics and Health Disparity Research (CGHDR) We seek NIH support to build an annex to the existing historic Carver Research Building to locate our cutting-edge cancer genomics research, focusing on translational computation biology research. The new addition will accommodate the growing needs of the many biomedical researchers at Tuskegee University pursuing computational and wet-lab genomics research and the many researchers that we will hire soon. This addition will thus provide a modern infrastructure consistent with the sophisticated requirements of current biomedical research and the training of a diverse workforce. Health disparities are a focus and point of distinction in biomedical research at Tuskegee University, an Institution of Emerging Excellence. Health disparities-related diseases are the leading causes of morbidity and mortality in the United States and are very poignantly exemplified during the current COVID-19 pandemic. African Americans continue to suffer disproportionately from these and other chronic diseases, including obesity and diabetes – all influenced by individual genetic predisposition and environmental and lifestyle factors, including diet, nutrition, and physical activity. Tuskegee University is located in Alabama’s Black Belt (a term initially referring to the area’s black topsoil and now more often its predominantly African American population). The city of Tuskegee and the Black Belt are among the poorest regions in the U.S. We seek to become a globally renowned center of emerging excellence in cancer genomics with a focus on health disparities. In the last few years, our cancer research efforts have been increasingly focused on genomics, transcriptomics, computational biology, and digital pathology, resulting in numerous grants and publications in high-impact journals. However, our existing laboratory infrastructure in an aging building has become drastically inadequate to support such modern research endeavors. Additionally, we have recently been awarded the prestigious NIH FIRST award in collaboration with UAB, which will require us to hire 12 new tenure track faculty members, with three housed at Tuskegee. These new faculty will put additional demands for sophisticated laboratory infrastructure that are not available in our current facilities. The Biomedical Research Center at Tuskegee University is currently housed in the historic Carver Research Foundation. It supports multiple complementary research programs, including the Research Centers at Minority Institutions (RCMI) and the Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham (UAB) Comprehensive Partnerships to Address Cancer Health Equity (CPACHE). The Integrative Biosciences Doctoral Program (IBS) is uniquely poised to explore the genomic profile of underserved populations within Alabama's Black Belt. Collectively, these programs promote biomedical research that facilitates the translation of basic research to innovative new therapeutics and behaviors to reduce health disparities within Alabama's Black Belt region and the southeast region. The new annex to the Carver Research Building will be the first facility on Tuskegee University's campus devoted solely to biomedical research and graduate education. The CGHDR will consist of approximately 8,000 ft2 of green/sustainable newly constructed space that will house wet lab benches; bioinformatics/genomic core research work areas; offices for faculty, trainees, graduate students, and administrative staff supporting these researchers; and conference rooms. The complex will include an open lab format that will support five new laboratories and three core laboratories (Microscopy, Bioinformatics, and Genomics/Proteomics/Molecular Biology). The Research Building will be the first LEED-certified building on the Tuskegee University campus and one of few in the Black Belt region. The proposed center will provide a location to identify novel strategies for preventing and treating disease and advance the capabilities of all biomedical researchers at Tuskegee University. The new center will undoubtedly contribute to research on reducing health disparities in Alabama's Black Belt region and beyond. The center will also provide a valuable infrastructure to several other research groups on the campus, including agricultural genomics and natural products research, nano-targeted drug delivery in the School of Engineering, and infectious diseases, meat and poultry safety, and pathobiology within the School of Veterinary Medicine. Furthermore, the new building will also help us attract and retain high-quality scientific talent, a chronic challenge in Tuskegee’s rural setting.