Center for Appalachian Research in Environmental Sciences - Analytical Chemistry Core for Environmental Sciences (ACCESS)

环境科学分析化学核心（Access） 肯塔基州大学阿巴拉契亚环境科学研究中心（UK-CARES） ACCESS将为中心研究者提供生物和环境样本分析的优先访问权 使用最先进的科学技术，服务和仪器进行与UK-CARES相关的研究。 三个科学主题：水传播污染物（水）的健康影响;室内和室内环境对健康的影响; 室外空气污染物（空气）;和新兴的环境健康威胁（新兴威胁）。 为了优化效率，ACCESS使用以下两个现有的实验室设施来利用资源 提供给这些设施，并扩大能力访问：环境化学和毒理学 实验室（农业食品与环境学院）和小分子质谱设备 （医学院），测量有机化学环境污染物，微量元素，其 代谢物和UK-CARES研究者感兴趣的相关分子。有效利用这些设施， UK-CARES研究者将需要常规分析和新方法开发和验证。 具体而言，ACCESS的目标1是提供环境化学品小组的测量。我们将 为检测和定量一系列卤化有机物提供技术上可靠的方法： 多氯联苯、二恶英、三卤甲烷和卤代乙腈、全氟和多氟烷基 物质、非卤化有机物，包括阻燃剂、环境酚和微量元素， 以支持跨翻译范围的EHS研究。目标2是开发或调整新的方法， 支持UK-CARES调查人员的持续需求。将重新开发方法或根据 文学我们将使用我们的Thermo TSQ Altis Plus三级四极杆质谱仪开发和 验证调查方法，这些方法可以使用单一的分析方法对多个类别的环境化学品进行分析 工作流程和使用高分辨率MS方法，采用我们的Thermo Exploris 240轨道阱质谱仪 用于在相关矩阵中对环境化学品进行无针对性的特征分析。空间分析技术， 微量分析和微量元素的形态分析是完善的环境健康研究使用我们的 Agilent 7900 ICP-MS和相关外围设备。目标3是与行政和数据管理 中心的职能，以实现强大的财政监督，项目管理，样品跟踪和数据 报告.我们将与综合健康科学设施核心和行政部门合作， 核心是确保中心成员获得优先访问权，ACCESS的活动符合 UK-CARES三个科学主题的战略愿景，服务和成果通过 在线IHSFC研究支持门户网站。ACCESS将提供可靠的、技术上可靠的方法， 服务，同时寻求创新的机会。核心方案提供的服务将支持英国关爱方案 成员致力为环境健康科学作出创新贡献。

PROJECT SUMMARY- Analytical Chemistry Core for Environmental Sciences (ACCESS) The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) ACCESS will provide Center investigators with priority access to biological and environmental sample analysis using state-of-the-science technologies, services, and instrumentation for studies related to the UK-CARES’ three science themes: Health Impacts of Waterborne Contaminants (WATER); Health Impacts of Indoor and Outdoor Airborne Contaminants (AIR); and Emerging Environmental Health Threats (EMERGING THREATS). To optimize efficiency, ACCESS uses the following two existing laboratory facilities to leverage resources available to these facilities and extend the capabilities ACCESS: the Environmental Chemistry and Toxicology Laboratory (College of Agriculture Food and Environment) and the Small Molecule Mass Spectrometry Facility (College of Medicine), to measure organic chemical environmental pollutants, trace-elements, their metabolites, and related molecules of interest to UK-CARES investigators. Effective use of these facilities by UK-CARES investigators will require both routine analysis and new method development and validation. Specifically, Aim 1 of ACCESS is to provide measurements of panels of environmental chemicals. We will provide technically robust methods for detection and quantification of a range of halogenated organics: polychlorinated biphenyls, dioxins, trihalomethanes and haloacetonitriles, per- and poly- fluorinated alkyl substances, non-halogenated organics including flame-retardants, environmental phenols, and trace-elements, to support EHS research across the translational spectrum. Aim 2 is to develop or adapt novel methods to support ongoing needs of UK-CARES investigators. Methods will be developed de novo or adapted from the literature. We will use our Thermo TSQ Altis Plus triple stage quadrupole mass spectrometer to develop and validate survey methods that can profile environmental chemicals in multiple classes using a single analytical workflow and use high-resolution MS methods employing our Thermo Exploris 240 orbitrap mass spectrometer for untargeted profiling of environmental chemicals in relevant matrices. Techniques for spatial analysis, microanalysis, and speciation analysis of trace-elements are refined for environmental health studies using our Agilent 7900 ICP-MS and associated peripherals. Aim 3 is to work with administrative and data management functions of the Center to enable robust fiscal oversight, project management, sample tracking and data reporting. We will work in tandem with the Integrated Health Sciences Facility Core and the Administrative Core to ensure that Center members receive priority access, that the activities of ACCESS are aligned with the UK-CARES strategic vision of the three science themes, and that services and outcomes are tracked through the online IHSFC Research Support Portal. ACCESS will provide reliable, technically robust methods and services while pursuing opportunities for innovation. Services provided by the core will support UK-CARES members’ efforts to make innovative contributions to environmental health science.