Developmental effects of antenatal exposure to antipsychotics

项目摘要/摘要 抗精神病药物是一类常用的药物，用于治疗多发性 精神病学中的适应症，包括精神病、情绪稳定和对 抑郁症。年，孕妇和哺乳期妇女中抗精神病药物的使用有所增加。 近几年来的频率。然而，它们的有效性还没有在这方面得到直接测试。 人口，以及关于艾滋病的潜在影响的许多悬而未决的问题 抗精神病药物对胎儿、新生儿和婴儿发育的影响。 我们建议对产妇精神病学病程进行前瞻性观察研究。 严重精神疾病女性的婴儿发育，与接受治疗的女性进行比较 对于接受其他药物治疗或不接受药物治疗的女性，使用抗精神病药物。初级阶段 研究结果将是母亲的精神复发，6岁婴儿的脑电异常 以及18个月时的行为和心理社会结果。我们希望能确定 抗精神病药物对患有严重精神疾病的孕妇是否有效？ 它们对婴儿发育有任何可衡量的影响。这些信息将帮助女性 严重的精神疾病会在知情的情况下决定她们在怀孕期间的护理。

Project Summary/Abstract Antipsychotics are a class of commonly used medications that are used for multiple indications within psychiatry, including psychosis, mood stabilization, and augmentation for depression. The use of antipsychotics among pregnant and lactating women has increased in frequency in recent years. However, their efficacy has not been directly tested in this population, and many unanswered questions remain about the potential effects of antipsychotics on the development of the fetus, neonate, and infant. We propose to conduct a prospective observational study of maternal psychiatric course and infant development among women with severe mental illness, comparing women treated with antipsychotics to women treated with other medications or without medication. The primary study outcomes will be psychiatric relapse in the mother, EEG abnormalities in the infant at 6 months, and behavioral and psychosocial outcomes at 18 months. We hope to determine whether antipsychotics are effective for pregnant women with severe mental illness and whether they have any measurable effects on infant development. This information will help women with severe mental illness make informed decisions about their care in pregnancy.