An inoculation theory-based messaging intervention addressing misinformation about HPV vaccine on social media: The Inoculate for HPV Vaccine randomized controlled trial

项目摘要 背景：社交媒体上的错误信息，或无意间分享虚假或不完整的信息 造成伤害，导致父母对疫苗犹豫不决，并阻碍HPV疫苗的接种 在美国的青少年中。可以快速开发的创新沟通策略 并部署以纠正社交媒体上不断演变的关于HPV疫苗的错误信息，并增加对 需要HPV疫苗。假设：我们假设基于理论的纠正信息直接 解决错误信息的内容将促进HPV疫苗系列的启动和完成，因为 与一般纠正消息和非消息控制组相比。建议：我们将高效地 使用自然语言处理(NLP)方法识别最近在社交媒体上传播的错误信息， 使用经过验证的消息测试协议开发和测试基于理论的纠正性消息传递工具，以及 评估该工具在提高青少年HPV疫苗系列启动率和完成率方面的效果 这是一项在线的三臂随机对照试验，并进行了纵向随访。参与者(n=2500) 将从社交媒体招募8-11岁青少年的父母，并在12个月内进行跟踪调查。 重要性和创新：如果成功，除了改善HPV疫苗接种情况外，来自 这项研究有可能被调整，以迅速和有效地处理其他形式的错误信息 公共卫生，如周围的COVID19、儿童疫苗接种或癌症预防和治疗 战略。

Project Summary Background: Misinformation on social media, or the sharing of false or incomplete information without intent to cause harm, is contributing to vaccine hesitancy among parents and impeding uptake of the HPV vaccine among adolescents in the United States. Innovative communication strategies that can be rapidly developed and deployed to correct evolving misinformation about HPV vaccine on social media and increase uptake of HPV vaccine are needed. Hypothesis: We hypothesize that theory-based corrective messages directly addressing the content of misinformation will improve HPV vaccine series initiation and completion as compared to general corrective messages and a non-message control group. Proposal: We will efficiently identify recently circulating misinformation on social media using natural language processing (NLP) methods, develop and test a theory-based corrective messaging tool using a validated message testing protocol, and assess the efficacy of the tool on increasing HPV vaccine series initiation and completion among adolescents in an online, block-randomized controlled trial with three arms and longitudinal follow-up. Participants (n=2500) will be parents of adolescents ages 8-11 recruited from social media and followed up over a 12-month period. Importance and Innovation: If successful, in addition to improving HPV vaccination uptake, the methods from this study have the potential to be adapted to address other forms of misinformation swiftly and efficiently in public health such as that surrounding COVID19, childhood vaccinations, or cancer prevention and treatment strategies.