Einstein BSL3 Laboratory Renovation to Advance Biomedical Research on RNA Viruses of Pandemic Potential

摘要 我们建议翻新阿尔伯特·爱因斯坦学院夏宁大楼的现有实验室空间 医学(爱因斯坦)，将扩展和改进现有的BSL-3和ABSL-3设施，以服务于不断增长的 我们的爱因斯坦研究人员的需求，他们对新兴的RNA病毒进行研究，最终目标是 疫苗和治疗学的发展。我们目前的小型病毒学BSL-3设施缺乏空间来满足 当前和预计的研究人员需求，并配备进行体外研究所需的设备 以及基于细胞的研究和对动物的研究。除了包括扩建的BSL-3和 ABSL-3空间(1497平方英尺，专门用于RNA病毒研究)，我们的计划包括建筑现代化 对固定设备和新的非固定科学设备的系统和投资，以加强和 简化实验室操作。此外，沙宁现有的BSL-3空间有温度控制系统 这些都是不足和迫切需要更新的；这将通过新的和独立的系统来缓解 温度、湿度和排气(专用的和多余的)。因此，我们请求为以下各项提供支持 AIMS，旨在扩大和升级我们现有的设施，为实验室提供新技术 支持、动物饲养和能源效率。在以下各节中，我们将介绍一个监督流程 将促进翻修进程的方方面面。目标1.对BSL-3整体空间进行现代化改造和扩展 Chanin大楼，用于新兴RNA病毒研究。目标2.为动物病毒研究建立基础设施 BSL-3水平。目标3.为改造后的实验室空间配备固定设备和新颖的非固定科学 设备将导致一个装备齐全的新兴RNA病毒BSL-3实验室空间。这项建议包括 机构支持，为该项目大量补充实验室设备，确保持续维护 改善所有设备和基础设施，并提供必要的人员支持。最后，爱因斯坦是 承诺提供试点资金，使更多的调查人员能够利用新设施并获得数据以支持赠款 申请资助具有大流行潜力的RNA病毒的研究。

ABSTRACT We propose to renovate existing laboratory space in the Chanin Building at the Albert Einstein College of Medicine (Einstein) which will expand and improve available BSL-3 and ABSL-3 facilities to serve the growing needs of our Einstein investigators who conduct research on emerging RNA viruses with the ultimate goal of vaccine and therapeutics development. Our current small virology BSL-3 facility lacks the space to meet current and projected investigator demand and to house the equipment needed to conduct cutting-edge in vitro and cell-based studies and work with animals. In addition to renovation that includes expanded BSL-3 and ABSL-3 space (1497 sq ft specifically for RNA virus research), our plan includes modernization of building systems and investments in fixed equipment and novel nonfixed scientific equipment to enhance and streamline laboratory operations. Further, the existing BSL-3 space in Chanin has temperature control systems which are inadequate and sorely in need of updating; this will be alleviated by new and independent system for temperature, humidity and exhaust (dedicated and redundant). We therefore request support for the following aims, which are intended to expand and upgrade our existing facility, with new technologies for laboratory support, animal holding, and energy efficiency. In the following sections, we describe an oversight process that will facilitate all aspects of the renovation process. Aim 1. Modernize and expand overall BSL-3 space in the Chanin Building for emerging RNA virus research. Aim 2. Create infrastructure for animal virus studies at the BSL-3 level. Aim 3. Furnish the renovated laboratory space with fixed equipment and novel nonfixed scientific equipment to result in a fully equipped emerging RNA virus BSL-3 laboratory space. This proposal includes institutional support to significantly supplement lab equipment for this project, ensure ongoing maintenance of all equipment and infrastructure improvements, and provide needed personnel support. Finally, Einstein is committing pilot funding to enable more investigators to utilize the new facility and obtain data to support grant applications to fund studies on RNA viruses with pandemic potential.