KL2 Training Program

辛辛那提大学临床和翻译科学与培训中心(CCTST)有一个 在培训KL2学者方面取得了优异的成绩。KL2计划任命了24名学者 (50%为女性，12.5%为任职人数不足)，自2009年以来来自不同学科(每年2名，为期2至3年 预约)。学者共发表稿件674篇，提交摘要792篇 在国家和国际科学会议上举办讲习班。在20名毕业生中，95%的人仍在指挥 临床和转化性研究(CTR)和100%担任过首席研究员(PI)或 外部资助的CTR赠款的调查员(Co-I)：20%的人已经过渡到职业PI 发展奖(CDA)，联邦独立拨款的PI获得65%，CDA或联邦政府的PI获得75% 独立赠款，联邦独立赠款的95%给PI或Co-I。毕业生曾担任过PIE 7枚R01，3枚国防部独立拨款，4枚R21，1枚R03，2枚R40，1枚R25，1枚R15，1枚U19，2枚K23，1枚 K25和1个美国心脏协会CDA。它们已作为3个U01的站点PI。直接成本之和 奖学金产生的收入为109,286,934美元。我们的团队越来越认识到需要解决以下问题 培养初级研究人员面临的挑战包括：1)招募和发展多样化的研究人员； 2)培训他们在广泛的核心CTR技能方面的能力；3)为他们成功地 进行团队科学；4)确保他们实现可持续和独立的职业生涯；5)培养活力 (职业投入、承诺和成就感)，尽管学术人员的职业倦怠程度越来越高； 6)鼓励他们将利益攸关方的优先事项纳入研究，并传播研究以改进 健康结果。因此，我们设计了我们的KL2奖学金计划来应对这些挑战，使用 循证策略，以实现以下具体目标：1)培养下一代临床和 通过有指导的研究经验、核心方法和技能发展的翻译研究人员，以及 量身定制的体验式学习机会；2)培养敬业、多样化的初级调查人员，这些调查人员具有 可持续的翻译研究事业；以及3)促进将学者研究转化为改进的 整个生命周期的健康结果。我们计划在CTSA中心和 可扩展到包括其他中心的创新数量，使用3D(开发、演示和 传播)方法。我们设计了一个严格的项目评估计划，包括NCATS Common 指标，纳入了广泛的研究道德培训，并制定了一项全面的计划，以 增加招聘和留住在生物医学研究中代表性不足的研究人员。 成功将以以下结果来衡量：1)我们招募多样化的、充满活力的学者；2)学者 获得拨款并在影响力较大的期刊上发表研究成果；3)学者开展持续、独立的研究 职业；以及4)学者的研究结果改善了健康结果。

The University of Cincinnati Center for Clinical and Translational Science and Training (CCTST) has an excellent record of accomplishment in training KL2 Scholars. The KL2 program has appointed 24 Scholars (50% women, 12.5% underrepresented) from diverse disciplines since 2009 (2 per year, for 2- to 3-year appointments). Scholars have published a total of 674 manuscripts and presented 792 abstracts and workshops at national and international scientific meetings. Of the 20 graduates, 95% are still conducting Clinical and Translational Research (CTR) and 100% have served as Principal Investigator (PI) or Co- Investigator (Co-I) of an externally-funded CTR grant: 20% have transitioned to PI of a career development award (CDA), 65% to PI of a federal independent grant, 75% to PI of a CDA or federal independent grant, and 95% to PI or Co-I of a federal independent grant. Graduates have served as PI of 7 R01s, 3 independent Department of Defense grants, 4 R21s, 1 R03, 2 R40s, 1 R25, 1 R15, 1 U19, 2 K23s, 1 K25, and 1 American Heart Association CDA. They have served as site PI of 3 U01s. The sum of direct costs generated by Scholars’ grants is $109,286,934. Our team has increasingly appreciated the need to address the challenges to developing junior researchers, including: 1) recruiting and developing diverse investigators; 2) training them to be competent in a broad spectrum of core CTR skills; 3) preparing them to successfully conduct team science; 4) ensuring that they achieve sustainable and independent careers; 5) fostering vitality (professionally engaged, committed, and fulfilled) despite increasing levels of burnout among academic faculty; and 6) encouraging them to integrate stakeholder priorities in research and disseminate research to improve health outcomes. As a result, we have designed our KL2 Scholars program to address these challenges using evidence-based strategies, to achieve the following Specific Aims: 1) Train the next generation of clinical and translational investigators through mentored research experiences, core methods and skills development, and tailored experiential learning opportunities; 2) Develop engaged, diverse junior investigators who have sustainable translational research careers; and 3) Promote the translation of Scholar research into improved health outcomes across the lifespan. We have planned several new collaborations across CTSA hubs and a number of innovations that can be scaled up to include other hubs, using the 3D (develop, demonstrate and disseminate) approach. We have designed a rigorous program evaluation plan including NCATS common metrics, have incorporated broad training in research ethics, and have developed a comprehensive plan to increase the recruitment and retention of investigators who are underrepresented in biomedical research. Success will be measured by the following outcomes: 1) we recruit diverse, vibrant Scholars, 2) Scholars secure grants and publish work in high-impact journals; 3) Scholars develop sustained, independent research careers; and 4) Scholars’ research results in improved health outcomes.