SWG1: Sex & Gender Working Group

项目概要/摘要：性与性别科学工作组1 在接受治疗和未接受治疗的艾滋病毒-1的表现方面，存在明显的性别差异 感染，但仍有待明确确定，这些是否是由于内在的差异， 免疫反应，对病毒的不同易感性，行为调节剂，激素 差异，或所有这些因素的组合。此外，尽管超过50%的艾滋病毒感染者 顺性别或跨性别女性，她们在临床研究中的注册人数不足，极大地限制了我们对性的理解 艾滋病毒感染、免疫机制和潜伏期、对抗逆转录病毒药物的反应， 和行为倾向，如由性别不平等和风险的社会经济挑战驱动的行为倾向。 暴力解决这些关于艾滋病毒的性和性别差异的关键知识差距，将有助于 制定有针对性的艾滋病毒预防、治疗和治愈战略，这对实现以下目标至关重要： 在全球范围内根除艾滋病毒感染。目前，CWRU和皮特的艾滋病毒研究社区的合并 成立锈带CFAR的申请使性与性别SWG 1能够组建一个特殊的 由基础、临床、翻译和行为研究人员组成的多学科团队，每个人都进行了 至少一项关于性别或性在艾滋病毒感染或治疗中的作用的研究，或具有与 跨性别社群性与性别问题工作组1将以每个机构的独特优势为基础， 与RUSTBELT CFAR核心紧密合作，以实现以下具体目标：（1）吸引CFAR成员 在涉及艾滋病发病机制的性别和性别差异的研究中。(2)为了便于将性别和 在治疗、预防和治疗相关的艾滋病毒研究中的性别差异。(3)在战略上协调 正式的指导计划，使初级研究人员了解研究性与性别的资源。成功 将根据一套明确界定的关键绩效指标对性与性别工作组1的绩效进行评估。因此，由 利用强大的艾滋病毒预防，发病机制和治疗研究，正在进行中的 RUSTBELT CFAR将其与我们在行为科学和公共卫生方面的专家相结合， SWG 1是理想的位置，以提供独特的见解，控制和管理的国家和全球 艾滋病毒流行病。

PROJECT SUMMARY/ABSTRACT: SEX & GENDER SCIENTIFIC WORKING GROUP 1 There are notable sex- and gender-specific differences in the manifestations of both treated and untreated HIV-1 infection, but it remains to be unequivocally determined whether these are due to intrinsic differences in immunological responses, differential susceptibility to the virus, behavioral modulators, effects due to hormonal differences, or a combination of all these factors. Moreover, although more than 50% of people with HIV are either cis- or transgender women, their under-enrollment in clinical studies has greatly limited our understanding of sex and gender differences in HIV acquisition, mechanisms of immunity and latency, responses to antiretroviral drugs, and behavioral tendencies, such as those driven by the socioeconomic challenges of gender inequity and risk of violence. Addressing these crucial knowledge gaps on sex and gender differences in HIV will facilitate the development of targeted strategies for HIV prevention, treatment, and cure, which are imperative to the goal of globally eradicating HIV infection. The merger of the HIV research communities at CWRU and Pitt in the current application to form the RUSTBELT CFAR has enabled the Sex & Gender SWG1 to assemble an exceptional multidisciplinary team of basic, clinical, translational, and behavioral investigators, each of whom has conducted at least one study on the role of gender or sex in HIV infection or treatment, or have expertise related to the transgender community. Building on the unique strengths of each institution, the Sex & Gender SWG1 will work closely with the RUSTBELT CFAR Cores to achieve the following Specific Aims: (1) To engage CFAR members in research involving sex and gender differences in HIV pathogenesis. (2) To facilitate incorporation of sex and gender differences in treatment, prevention, and cure-related HIV research. (3) To strategically coordinate a formal mentorship program to make junior investigators aware of resources to study Sex & Gender. The success of the Sex & Gender SWG1 will be evaluated based on a well-defined set of key performance metrics. Thus, by taking advantage of the strong HIV prevention, pathogenesis, and cure research that is ongoing within the RUSTBELT CFAR and combining it with our experts in behavioral sciences and public health, the Sex & Gender SWG1 is ideally placed to provide unique insights into the control and management of the national and global HIV epidemics.