Frontiers in Reproduction (FIR) Training Course

项目摘要：此R25申请为我们的高级培训课程寻求五年的赞助 题为：生殖前沿(FIR)，每年在伍兹霍尔的MBL举行，由Dr。 拉斐尔·A·费索尔(马萨诸塞州阿默斯特大学)。本课程面向高级研究生、博士后。 致力于基础、翻译或临床研究的研究员和内科科学家 生殖生物学领域。FIR向参与培训的学员介绍该领域最先进的研究成果， 横跨生殖内分泌学、生殖细胞和器官发育、配子发生和植入以及 胎盘和辅助生殖技术(ART)。我们为学员提供基本概念， 具有“尖端”研究和实验室技术知识，职业指导和伦理指导， 生殖研究的法律和社会影响。为了实现这一目标，我们提出了以下具体建议 目标：1)提供一系列连贯的讲座，涵盖广泛领域的基本概念 生殖生物学，并向学生介绍该领域的公开问题。2)提供讲座和 讨论艺术中的新兴概念和技术及其应用。3)培养高中生 探索生殖的细胞和器官功能所需的细胞和分子技术 通过最先进的、实际操作的演示和微型项目。4)提供就业机会 通过提供有关科学交流、数据分析和口语的培训来规划和推进 演示文稿。5)教育受训人员关于使用人类和动物时的伦理考虑；以及 关于使用动物作为研究模型。6)营造多元、合群的环境，促进长期合作 学员之间以及学生和教职员工之间的导师关系和合作。FIR被划分为 分成三个专题科学部分，每个部分持续两周。课程每周5-6天，每天两堂课。 和动手的实验室练习。FIR不断整合新的教师、主题和技术 突破，确保练兵始终走在前列。该课程将提供一个重要的 通过培训生殖生物学和生物医学领域的新研究人员，有利于生物医学研究 生物技术和艺术。生殖科学是一个广泛和成熟的领域，在 并在NIH的整个投资组合范围内产生生物医学影响。

Project Summary: This R25 application seeks five years of sponsorship for our advanced training course entitled: Frontiers in Reproduction (FIR), held annually at the MBL in Woods Hole under the Directorship of Dr. Rafael A. Fissore (UMass, Amherst). The course is directed towards advanced graduate students, post-doctoral fellows, and physician-scientists who are committed to fundamental, translational or clinical research studies in the field of reproductive biology. FIR introduces participating trainees to state-of-the-art research in the field, spanning reproductive endocrinology, germ cell and organ development, gametogenesis and implantation and placentation, and Assisted Reproductive Technologies (ART). We provide trainees with fundamental concepts, knowledge of “cutting edge” research and laboratory techniques, career mentoring and instruction in the ethical, legal, and societal impact of research in reproduction. To achieve this goal, we propose the following specific aims: 1) Provide a coherent series of lectures covering fundamental concepts spanning the broad field of reproductive biology and introducing students to the open questions in the field. 2) Provide lectures and discussions on the emerging concepts and techniques in ART and its applications. 3) Train students in advanced cellular and molecular techniques required to probe the cellular and organ function underlying reproduction through state-of-the-art and hands-on demonstrations and mini-projects. 4) Provide opportunities for career planning and advancement by offering training on scientific communication, data analysis, and oral presentations. 5) Educate trainees on the ethical considerations involved in the use of human and animals, and on the use of animals as research models. 6) Foster a diverse, collegial environment that leads to long-term mentorship relationships and collaborations among trainees and between students and faculty. FIR is divided into three topical scientific sections, each lasting 2 weeks. The course meets 5-6 days a week with 2 daily lectures and hands-on laboratory exercises. FIR continually incorporates new faculty, topics and technological breakthroughs to ensure that the training remains at the forefront of the field. The course will provide a significant benefit to biomedical research through the training of new investigators in the field of reproductive biology and biotechnology, and ART. Reproductive science is a broad and well-established field with enormous impact in society and with biomedical implications across the entire spectrum of NIH’s portfolios.