UNC MACS/WIHS Combined Cohort Study Clinical Research Site

项目摘要/摘要 本申请建议建立北卡罗来纳大学教堂山分校作为临床研究 多中心艾滋病队列研究(MACS)/妇女机构间艾滋病毒研究(WIHS)联合站点(CRS) 队列研究(MACS/WIHS-CCS)。该提案代表了来自 北卡罗来纳大学全球卫生和传染病研究所，北卡罗来纳大学吉林斯学院艾滋病研究中心 全球公共卫生部、莱恩伯格综合癌症中心、伊谢曼药学院和塞西尔 G.谢普斯卫生服务研究中心。 我们建议迅速建立UNC MACS/WIHS-CCS CRS，为MACS/WIHS做出有意义的贡献- CCS(CCS)统一科学议程，并进行雄心勃勃的研究，包括肺， 心血管、神经认知和其他与艾滋病毒相关的合并症；艾滋病毒的发病/治疗；社会 流行病学和健康结果；行为研究；以及先进的流行病学方法。 我们的目标是：(1)招募310名反映美国东南部艾滋病毒流行情况的男性和女性参与者， 并重新同意现有的WIHS参与者参与CCS；(2)领导CCS的关键组件 统一科学议程；(3)在北卡罗来纳大学CRS支持CCS科学议程的所有方面。 通过贡献具有代表性的男性和女性、创新的科学和强大的 多学科干部调查员，UNC将加强CCS的努力，扩大调查范围 可以解决的问题，并与整个小组合作，改善男性和 感染艾滋病毒或处于感染艾滋病毒高危状态的妇女。

PROJECT SUMMARY/ABSTRACT This application proposes to establish The University of North Carolina at Chapel Hill as a Clinical Research Site (CRS) for the Multicenter AIDS Cohort Study (MACS)/Women’s Interagency HIV Study (WIHS) Combined Cohort Study (MACS/WIHS-CCS). The proposal represents a collaborative effort between investigators from The UNC Institute for Global Health and Infectious Diseases, Center for AIDS Research, UNC Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, Eshelman School of Pharmacy, and Cecil G. Sheps Center for Health Services Research. We propose to rapidly establish the UNC MACS/WIHS-CCS CRS, contribute meaningfully to the MACS/WIHS- CCS (CCS) Unified Science Agenda, and undertake ambitious research that encompasses pulmonary, cardiovascular, neurocognitive, and other HIV-related comorbidities; HIV pathogenesis/cure; social epidemiology and health outcomes; behavioral research; and advanced epidemiologic methods. We aim to: (1) Enroll 310 male and female participants who reflect the HIV epidemic in the southeastern US, and re-consent current WIHS enrollees for participation in the CCS; (2) Lead critical components of the CCS Unified Science Agenda; (3) Support all aspects of the CCS Science Agenda at the UNC CRS. By contributing a representative population of men and women, innovative science, and a strong, multidisciplinary cadre of investigators, UNC will enhance the efforts of the CCS, expand the range of questions that can be addressed and, in collaboration with the entire group, improve the health of men and women with or at high risk for HIV infection.