Brain Inhibition Control and Child Obesity Risk

项目摘要 儿童肥胖率一直在急剧上升，为医疗保健和福祉付出了巨大代价。它 肥胖很可能会持续到成年;因此，确定导致儿童肥胖的危险因素， 肥胖症极为严重，因此可以及早采取预防策略，以降低肥胖率。 研究表明，在子宫内暴露于妊娠期糖尿病（GDM）的儿童， 增加发展肥胖的倾向。然而，很少有人类研究旨在了解 解释这种关系的机制。申请人K 01项目的主要目标是调查 GDM暴露与涉及食欲调节的大脑通路之间的关联， 代谢和奖赏途径。该R 03项目的总体目标是扩展 申请人正在进行的K 01研究，以检验子宫内暴露于GDM可能破坏 前额抑制控制电路，导致暴饮暴食和肥胖。为了实现这一目标， 申请人和她的团队计划利用青少年大脑提供的大脑和肥胖数据 认知发展（ABCD）研究，以及1）调查GDM暴露与 抑制控制的功能/结构相关性;以及2）使用基于大脑的标记物来预测 肥胖症这将是人类使用多模态成像技术检查神经系统的最大研究。 GDM暴露与肥胖风险之间的联系机制。 拟议的研究是申请人K 01项目的延伸，共同将允许 候选人对参与食欲调节的大脑回路进行全面评估，并建立 一个基于大脑的工作模型解释了子宫内暴露于GDM的儿童肥胖风险增加。

Project Summary Childhood obesity rate has been increasing dramatically, at great cost for health care and wellbeing. It is highly likely that obesity will persist into adulthood; thus, identifying risk factors contributing to childhood obesity is extremely critical so that prevention strategies can be taken early to reduce the obesity rate. Research suggests that children who were exposed to gestational diabetes mellitus (GDM) in utero have increased propensity of developing obesity. However, there are few human studies aimed to understand the mechanisms explaining this relationship. The primary goal of the applicant’s K01 project was to investigate associations between GDM exposure and brain pathways implicated in appetite regulation, particularly metabolic and reward pathways. The overall goal of this R03 project is to extend findings from the applicant’s ongoing K01 study to test a hypothesis that in utero exposure to GDM may disrupt the prefrontal inhibition control circuitry, resulting in overeating and obesity. To accomplish this goal, the applicant and her team plan to leverage brain and adiposity data available through the Adolescent Brain Cognitive Development (ABCD) study, and 1) investigate relationships between GDM exposure and functional/structural correlates of inhibition control; and 2) use brain-based markers to predict changes in adiposity. This will be the largest study in humans to use multi-modal imaging techniques to examine neural mechanisms of the link between GDM exposure and obesity risk. The proposed study is an extension of the applicant’s K01 project, together by which will allow the candidate to have a comprehensive assessment of brain circuitry involved in appetite regulation and establish a brain-based working model explaining increased obesity risk among children exposed to GDM in utero.