Training Program in Precision Genetics of Aging, Alzheimer's Disease and Related Dementias

项目摘要/摘要 杰克逊实验室(JAX)自成立以来一直是哺乳动物遗传学研究和教育的领先者 成立于1929年。贾克斯开创了用遗传学方法理解基础知识的先河 哺乳动物发育中的问题和人类疾病的基因基础。贾克斯也有一个很长的 以及培养博士后和博士后学者的杰出记录，使其富有成效 系统遗传学、基因组学和计算生物学结合部的研究人员。要支持JAX的DUAL 以发现和教育为使命，我们不断努力提供尖端、独特和高度相关的 培训机会旨在使所有日本宇宙航空研究开发机构的受训人员为成功的科学事业做好准备。 NIA T32资助的衰老和痴呆症精确遗传学(PGAD)培训计划将 提供高质量的研究生和博士后培训，为学员独立工作做好准备 大学、研究机构和生物医药行业的研究人员。它将把16个高度 位于缅因州巴尔港的JAX哺乳动物遗传学园区的高效且资金充足的教师导师 位于康涅狄格州法明顿的JAX基因组医学园区，提供独特的跨学科、集成和 综合训练环境。在老龄化和与年龄相关的疾病方面的研究重点包括 哺乳动物遗传学、血液学、血管生物学、免疫学、肾脏学、神经病学、行为学、微生物群、 系统遗传学和生物信息学。 我们寻求为博士后研究员提供两个名额，并请求为两名博士后学生提供支持。 贾克斯参加了与加州大学塔夫茨医学院的合作博士培训项目 缅因州和康涅狄格大学已经发展到临界点。具体的标准被用来承认这两个 博士后和博士后实习生加入该计划。开发了必修课和选修课，以丰富 训练经验。受训者将测试关于衰老和疾病的遗传基础的假设， 并将利用尖端的计算和小鼠遗传学建立新的诊断和治疗模式 在JAX上为他们提供唯一可用的资源。学员将有机会获得专注和个性化的职业生涯 发展机会，如教学和赠款编写经验，并将纳入研讨会， 研讨会和研究兴趣小组。他们将撰写外部资金申请，并将他们的发现提交给 科学会议，并在同行评议的期刊上发表。实习生评估将是严格的，并与 支持增长。因此，该计划将在一个激动人心的科学研究领域提供特殊的研究机会 培训环境，并使受训者能够在生物医学研究领域开始成功的独立职业生涯。

PROJECT SUMMARY/ABSTRACT The Jackson Laboratory (JAX) has been a leader in mammalian genetics research and education since its inception in 1929. JAX pioneered the development of genetic approaches toward understanding fundamental questions in mammalian development and the genetic underpinnings of human disease. JAX also has a long and illustrious track record of training postdoctoral, and more recently predoctoral scholars, to be productive researchers at the nexus of systems genetics, genomics and computational biology. To support JAX's dual mission of discovery and education, we continually strive to provide cutting-edge, unique, and highly relevant training opportunities designed to prepare all JAX trainees for successful scientific careers. An NIA T32–funded Training Program in Precision Genetics of Aging and Dementia (PGAD) would provide high-quality graduate and postdoctoral training to prepare its trainees for careers as independent investigators in universities, research institutions and the biomedical industry. It would bring together 16 highly productive and well-funded faculty mentors at the JAX Mammalian Genetics campus in Bar Harbor, ME and the JAX Genomic Medicine campus in Farmington, CT who provide a uniquely interdisciplinary, integrated and comprehensive training environment. Research foci within the context of aging and age-related disease include mammalian genetics, hematology, vascular biology, immunology, nephrology, neurology, behavior, microbiome, systems genetics, and bioinformatics. We seek to provide two slots for postdoctoral fellows, and request support for two predoctoral students. JAX participates in collaborative Ph.D. training programs with the Tufts School of Medicine, the University of Maine, and the University of Connecticut that have grown to critical mass. Specific criteria are used to admit both pre- and postdoctoral trainees into the program. Required and elective curricula have been developed to enrich the training experience. Trainees will test hypotheses regarding the genetic underpinnings of aging and disease, and will model new diagnostic and therapeutic modalities, using cutting-edge computational and mouse genetics resources uniquely available to them at JAX. Trainees will have access to focused and individualized career development opportunities, such as teaching and grant writing experiences, and will be integrated into seminars, workshops, and research interest groups. They will write external funding applications, present their findings at scientific meetings, and publish in peer-reviewed journals. Trainee evaluation will be rigorous and coupled with support for growth. The program will thus provide exceptional research opportunities in a stimulating scientific training environment and enable trainees to launch successful independent careers in biomedical research.