Core A - Administrative

核心A -项目总结/摘要 这是一个持续的计划项目，有多个项目，核心，机构和调查人员， Zilkha神经遗传学研究所，史蒂文斯神经成像和信息学研究所，阿尔茨海默病研究 中心（ADRC），南加州大学，洛杉矶，加利福尼亚州;华盛顿大学奈特ADRC和 密苏里州圣路易斯市神经科;加利福尼亚州帕萨迪纳市亨廷顿医学研究所;班纳 阿尔茨海默氏症研究所和梅奥诊所，亚利桑那州;心理科学系，加州大学欧文分校;和部门 斯克里普斯研究所的分子医学中心;和临床脑科学中心， 苏格兰爱丁堡也将加入该计划。P01已经并将继续作为一个整体发挥作用 远远大于各部分的总和。每个项目和核心都是对其他项目的补充， 它们之间的关系是通过共同关注计划的目标来实现的，即测试 AD的神经血管假说行政核心的结构是为了确保这个程序的功能， 尽可能高效、高效和透明。核心A的目标仍然旨在提供有效的 科学和行政领导的计划，并确保跨项目的有效沟通 和核心。鉴于该计划项目有多个地点，并与其他资助的工作有联系， 我们管理这些努力，以确保纳入/排除标准，临床和 神经心理学评估，以及认知未受损、轻度认知受损和 痴呆核心A通过委员会、文件、网站资源和内部和外部资源促进这些目标的实现。 外部审查（SAB）。本核心的目标反映了MPI、Zlokovic博士和Toga博士的承诺， 为由3个研究项目和3个核心组成的计划提供科学和行政领导， 这些都是集成的，并使用互补的方法，技术和分析集中在该计划 项目的广泛目标，如概述中所述。核心A的目标是：1。提供科学和 行政领导，以确保统一和一致的参与者筛选和登记，在不同的 参与研究中心;项目、核心、Co-I和SAB成员之间的透明沟通;以及开放数据 在所有Co-Is之间共享，以及在不同机构之间共享各自的临床和科学人员 作为更广泛的科学界。2.跟踪整个计划的里程碑和度量指标， 对于所有项目和核心，我们将保持研究的内部质量控制，并每月举行所有项目和核心的会议。 PL、CL和Co-Is，AIM 1小组委员会季度会议以及特别和年度评估 与我们的SAB成员举行会议，以有效地监督计划的发展，并保持高质量的 科学进步。3.为教育做贡献。4.利用商业模式有效管理 计划的业务活动，包括日常活动的管理，合同协议，分配 定期收入/支出报告。

CORE A – PROJECT SUMMARY/ABSTRACT This is a continuing program project with multiple projects, cores, institutions and investigators from the Zilkha Neurogenetic Institute, Stevens Neuroimaging and Informatics Institute, Alzheimer’s Disease Research Center (ADRC), University of Southern California, Los Angeles, CA; Washington University Knight ADRC and Department of Neurology, St. Louis, MO; Huntington Medical Research Institutes, Pasadena, CA; Banner Alzheimer’s Institute and MayoClinic, Arizona; Department of Psychological Science, UC Irvine; and Department of Molecular Medicine, the Scripps Research Institute; and Centre for Clinical Brain Sciences, University of Edinburgh, Scotland will also join the program. The P01 has and will continue to function as an integrated whole far greater than the sum of its parts. Each project and core complements the others so that a synergistic relationship among them is achieved with a common focus on goals of the program, namely to test the neurovascular hypothesis of AD. The Administrative Core is structured to insure that this program functions as efficiently, productively and transparently as possible. The goals of Core A remain designed to provide effective scientific and administrative leadership for the program and ensure effective communications across projects and cores. Given that this program project has multiple sites and linkages to other funded efforts, it is essential that we manage these efforts to insure harmonization of inclusion/exclusion criteria, clinical and neuropsychological evaluations, and diagnostic criteria for cognitively unimpaired, mild cognitive impairment and dementia. Core A facilitates these goals with committees, documentation, website resources and internal and external (SAB) reviews. The Aims of this Core reflect the commitment of the MPIs, Drs. Zlokovic and Toga, to provide the scientific and administrative leadership for the program consisting of 3 research projects and 3 cores, which are all integrated and use complementary approaches, technologies and analyses focused on the program project’s wide aims as described in the Overview. The Aims of Core A are: 1. To provide scientific and administrative leadership to ensure unified and consistent participant screening and enrolment across different participating sites; transparent communication across projects, cores, Co-Is and SAB members; and open data sharing among all the Co-Is, their respective clinical and scientific personnel across different institutions as well as the wider scientific community. 2. To track milestones and metric measures for the program as a whole and for all projects and cores, we will maintain internal quality control of research and hold monthly meetings of all PLs and CLs and Co-Is, quarterly meetings of subcommittees from AIM 1 and ad hoc and annual evaluation meetings with our SAB members to effectively monitor development of the program and maintain high-quality scientific progress. 3. To contribute to education. 4. To utilize business models to efficiently manage the program’s business activities including management of day-to-day activities, contractual agreements, allocation of funds, and regular income/expense reports.