Biospecimen Core

项目摘要-Biospecimen核心(核心C) 与临床数据相关联的生物旋毛虫的获取、表征和研究进展 与患者相关的临床前模型是有效和有影响力的翻译的基本组件 研究。Dana Farber/哈佛癌症中心(DF/HCC)前列腺孢子生物素核心(核心) C)将维持和扩大一个成熟的前列腺癌生物库，包括血液和组织标本， 来自DF/HCC的不同前列腺癌患者，他们同意我们的临床 数据库和生物库协议。Core C将提供组织标本和丰富的病理学专业知识 孢子调查人员包括对人类和小鼠模型组织的评估。核心C将 维护所有同意的患者的临床数据数据库，并与标准化的病理审查相联系 程序和数据收集。CORE C将与孢子调查人员和合作者密切合作， 提供解释和咨询病理学服务，包括最先进的分子分析 以及在DF/HCC开发的成像技术。核心活动的集中化建立在 已建立的基础设施，但不复制DF/CC内的现有资源。总体而言，核心C 将通过以下途径极大地促进和加速DF/HCC前列腺癌孢子内的翻译研究 高度注释的生物材料和相关临床信息的收集和整合。

PROJECT SUMMARY – BIOSPECIMEN CORE (CORE C) Acquisition and characterization of biospecimens linked with clinical data and the development of patient­ relevant preclinical models, are essential components for effective and impactful translational research. The Dana Farber/ Harvard Cancer Center (DF/HCC) Prostate SPORE Biospecimen Core (Core C) will maintain and expand a mature prostate cancer biorepository, including blood and tissue specimens, from a diverse group of prostate cancer patients across DF/HCC who have provided consent to our clinical database and biobank protocols. Core C will provide tissue specimens and vast pathology expertise to SPORE investigators including the evaluation of both human and mouse model tissues. Core C will maintain a database of clinical data on all consented patients, linked with standardized pathology review procedures and data collection. Core C will work closely with SPORE investigators and collaborators to provide interpretative and consultative pathology services, including state­of­the­art molecular assays and imaging technologies developed at DF/HCC. Centralization of Core activities builds upon established infrastructure but does not replicate existing resources within the DF/HCC. Overall, Core C will greatly facilitate and accelerate translational research within the DF/HCC Prostate SPORE through the collection and integration of highly annotated biological material and associated clinical information.