NOX isoforms in diabetes associated vascular injury: implications for therapeutic strategies
NOX isoforms in diabetes associated vascular injury: implications for therapeutic strategies
批准号:
nhmrc : 1005851
负责人:
A/Pr Judy De Haan
金额:
$29.44万
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31
中文摘要
这些研究将调查氧化应激和参与氧化应激产生的酶在糖尿病相关血管损伤和肾损伤中的作用,这些损伤会导致心脏病发作、中风和肾衰竭。我们将使用独特的基因敲除动物模型和新的药物治疗方法。最终,我们的目标是开发新的治疗方法,以更好地治疗和预防糖尿病相关并发症。
英文摘要
These studies will investigate the role of oxidative stress and enzymes involved in oxidative stress production in diabetes associated blood vessel injury and kidney damage, leading to heart attacks, stroke and kidney failure. We will use unique knockout animal models and novel drug treatments. Ultimately, we aim to develop novel treatments to better treat and prevent diabetes related complications.
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会议论文
Antioxidant glutathione peroxidase (GPx) mimetics and atherosclerosis: a role for targeted antioxidant therapy.
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批准号:nhmrc : 526656
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项目类别:NHMRC Project Grants
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资助金额:$23.89万
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财政年份:2009
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负责人:A/Pr Judy De Haan
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依托单位:
Cytosolic oxidative disturbances as a source of mitochondrial dysfunction in diabetic nephropathy
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批准号:nhmrc : 526639
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项目类别:NHMRC Project Grants
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资助金额:$33.73万
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财政年份:2009
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负责人:A/Pr Judy De Haan
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依托单位:
海外基金