Investigating relationships between naturalistic light exposure and sleep

项目总结 睡眠不规律非常普遍，并与下游不利的心脏代谢健康结果有关，但 睡眠不规律的上游驱动因素并没有得到很好的描述。与以下疾病相关的不良健康后果 不规律的睡眠时间反映了与倒班工作有关的睡眠时间，而不规律的睡眠可能代表了昼夜节律的驱动因素 在普通人群中出现错位和相关疾病。值得注意的是，睡眠时间是可修改的，并且可以 作为一种廉价、非侵入性的促进健康的方式，但对环境因素进行进一步研究 影响睡眠规律是成功的干预措施所必需的。了解环境问题 睡眠不规律的驱动因素和分子标记是有助于公共卫生干预和 疾病预防工作。 最近的2021年美国国立卫生研究院睡眠研究计划强调了环境暴露对健康影响的研究 睡眠以及睡眠和昼夜健康的表观遗传机制是最优先考虑的。因此，要 为了解决这些知识差距和既定的研究需求，我建议在睡眠中应用后天训练 流行病学、时间生物学、高级统计分析和表观遗传学：1)调查 光照维度通过年龄和性别等因素影响睡眠规律性和节制(K99)，2 开发睡眠规律的生物标记物(K99)，3)验证和建立结果的时间性 使用前瞻性收集的数据(R00)得出的结果，以及4)扩展了对光线和环境的测量 前瞻性收集数据的因素(R00)。 我的目标是建立一个独立的研究项目，以光和其他环境如何 暴露会影响睡眠和人群健康的时间生物学。这项建议的学习和职业发展 从逻辑上讲，PLAN建立在我在环境健康、视觉研究和分子流行病学方面的培训基础上，以 获得光数据分析和收集、睡眠流行病学、时间生物学、高级统计学方面的专业知识 建模和组学集成。在Tamar Sofer博士提供的专家指导下，Susan博士 Redline和Frank Scheer博士，我将建立一个独特的跨学科研究计划，专注于 光环境与睡眠的相互作用。该奖项将在四个方面提供关键培训：1)睡眠 流行病学；2)临床时间生物学；3)高维光和活动成像的集成和分析 数据与组学数据；4)专业发展。在R00阶段期间收集的数据也将 为R01应用提供坚实的基础。这一奖项提供的支持将使我能够发起一项 新颖的独立研究计划，解决了我们对自然主义的作用的理解中的固有空白 光照对普通人群睡眠健康的影响。

PROJECT SUMMARY Sleep irregularity is highly prevalent and linked to downstream adverse cardiometabolic health outcomes, but the upstream drivers of sleep irregularity are not well characterized. Adverse health outcomes associated with irregular sleep timing mirror those linked to shift work, and irregular sleep may represent a driver of circadian misalignment and related disease in the general population. Notably, sleep timing is modifiable and could serve as an inexpensive, non-invasive way to promote health, but further research on environmental factors influencing sleep regularity is required to inform successful interventions. Understanding the environmental drivers and molecular markers of irregular sleep are critical gaps that would aid public health intervention and disease prevention efforts. The recent 2021 NIH Sleep Research Plan highlights research on the effects of environmental exposures on sleep and on epigenetic mechanisms underlying sleep and circadian health as top priorities. Therefore, to address these gaps in knowledge and stated research needs, I propose to apply acquired training in sleep epidemiology, chronobiology, and advanced statistical analysis and epigenetics to: 1) investigate which dimensions of light exposure impact sleep regularity and moderation by factors such as age and sex (K99), 2) develop biological markers of sleep regularity (K99), 3) validate and establish the temporality of resulting findings with prospectively collected data (R00), and 4) expand measurement of light and environmental factors with prospectively collected data (R00). My goal is to establish an independent research program centered around how light and other environmental exposures affect sleep and chronobiology in population health. This proposed study and career development plan logically builds upon my training in environmental health, vision research, and molecular epidemiology, to gain expertise in light data analysis and collection, sleep epidemiology, chronobiology, advanced statistical modeling, and omics integration. With expert mentored guidance provided by Dr. Tamar Sofer, Dr. Susan Redline, and Dr. Frank Scheer, I will establish a unique interdisciplinary research program focusing on the interactions of the light environment and sleep. This award will provide key training in four areas: 1) sleep epidemiology; 2) clinical chronobiology; 3) integration and analysis of high-dimensional light and actigraphy data with omics data; and 4) professional development. This data collected during the R00 phase will also provide a strong foundation for R01 applications. This support provided by this award will allow me to launch a novel independent research program and address inherent gaps in our understanding of the role of naturalistic light exposure on sleep health in the general population.