Interoception as a Novel Risk Factor for Suicidal Thoughts and Behaviors

项目摘要 自杀是全世界的主要死因，也是世界青少年的第二大死因。 我们尽管对自杀想法和行为及其治疗的理解有所进步， 并没有减少。限制这一领域进展的一个可能因素是， 了解（和针对）可能引起自杀想法的发展机制， 行为。内感受，即对内部身体状态的感知，有望成为一种新的因素， 增加自杀风险。自杀的想法和行为围绕着对身体造成伤害，然而， 令人惊讶的是，很少有工作测试了内感受性过程的中断是否以及如何可能导致 自杀考虑到身体在自杀念头和行为中的中心地位， 学习和处理可能发生在青春期，改变内感受性处理代表了一个 新的危险因素，可能会促进对青少年自杀想法和行为的理解。这 该提案测试了内感受过程与自杀念头发生之间的关联， 行为。80名有和没有自杀想法和行为的青少年将接受以下评估： 自杀想法和行为，内感受过程的心理生理学测量，暴露于 童年创伤，以及对自杀想法和行为的生态瞬时评估和评价 身体的感觉。本提案的目的1是测试知觉内感受性之间的关联 过程（即，内感受准确性、敏感性和注意力）与自杀想法和行为之间的关系。目标2 这项建议是为了检验身体感觉的评价和描述与自杀之间的联系。 思想和行为。本提案的目的3是测试内感受过程是否是一种潜在的 儿童创伤与自杀想法和行为之间的关联的中介。拟议 研究的最大潜在影响是使用创新策略来研究一种新的潜在风险因素， 自杀想法和行为，确定具有明确转化价值的推定途径，并 潜在地确定新的干预目标，以治疗青少年的自杀想法和行为。

Project Summary Suicide is a leading cause of death worldwide and the second leading cause of death for adolescents in the US. Despite advances in understanding of suicidal thoughts and behaviors and their treatment, the suicide rate has not decreased. One possible factor limiting progress in this area has been a lack of focus on understanding (and targeting) developmental mechanisms that may give rise to suicidal thoughts and behaviors. Interoception, the perception of internal bodily states, holds promise as a novel factor that may increase risk for suicide. Suicidal thoughts and behaviors center around inflicting harm to the body, yet surprisingly little work has tested whether and how disrupted interoceptive processes may contribute to risk for suicide. Given the centrality of the body in suicidal thoughts and behaviors and the unique interoceptive learning and processing that may occur during adolescence, altered interoceptive processing represents a novel risk factor that may advance understanding of suicidal thoughts and behaviors among adolescents. This proposal tests the associations between interoceptive processes and the occurrence of suicidal thoughts and behaviors. Eighty adolescents with and without suicidal thoughts and behaviors will undergo assessments of suicidal thoughts and behaviors, psychophysiological measurement of interoceptive processes, exposure to childhood trauma, and ecological momentary assessments of suicidal thoughts and behaviors and appraisals of body sensations. Aim 1 of this proposal is to test the association between perceptual interoceptive processes (i.e., interoceptive accuracy, sensitivity, and attention) and suicidal thoughts and behaviors. Aim 2 of this proposal is to test the association between appraisals and descriptions of body sensations and suicidal thoughts and behaviors. Aim 3 of this proposal is to test whether interoceptive processes are a potential mediator of the associations between childhood trauma and suicidal thoughts and behaviors. The proposed study’s greatest potential impacts are to use innovative strategies to study a novel potential risk factor for suicidal thoughts and behaviors, identify putative pathways that have clear translational value, and to potentially identify novel targets for intervention to treat suicidal thoughts and behaviors in adolescents.