Developmental Biology of the Sea Urchin and Marine Invertebrates (DBSUMI) Meeting XXVII

会议理由。2023年10月，世卫组织国际社会利用海洋无脊椎动物 作为研究模型，以解决发育、细胞、生态和 进化生物学将满足海胆和其他海洋生物的发育生物学 无脊椎动物（DBSUMI）。这将是该会议的第27次论坛， 从1980年开始每18个月这些年来，这些会议的主题是 与广泛的生物学家有关，这些生物学家研究的主题包括配子相互作用、卵 激活，细胞命运确定和模式化，轴特化，基因表达，基因组学， 形态发生，细胞信号，进化，生态学，免疫学，神经发生，再生和 实验技术 重要的是，这些领域的进展不仅适用于海胆， 生物系统。为了促进这些广泛的发现，最初的“海胆社区”已经 通过邀请从事细胞和发育生物学的研究人员， 其他海洋无脊椎动物模型，包括被囊动物，半索动物，头索动物，软体动物， 多毛类、刺胞动物、栉水母和海绵。每个模型都有自己独特的回答能力 这些基本问题可以解决与人类发展、健康和疾病有关的问题。的 比较研究的概念基础在于它们能够确定机制的共同点 和过程，这反过来又揭示了生物学的统一原则。著名 海洋生物研究中的重大发现包括我们对细胞的了解， 分裂和细胞周期蛋白，微管运动驱动蛋白的作用，GFP和 其他荧光蛋白作为生物医学科学中广泛使用的工具。 因此，我们的目标是将DBSUMI确立为实验室“必须参加”的会议 使用海洋无脊椎动物模型系统来回答一系列广泛的问题， 与人类发展和健康密切相关。该计划的一个核心重点是 促进科学家之间的深入讨论。讲座、讨论会和 非正式的社交聚会使不同系统的调查结果得以整合。DBSUMI XXVII和 它的未来迭代将是这个科学界的成长和活力所不可或缺的， 在广泛的海洋无脊椎动物模型中， 任何细胞、进化和/或发育生物学会议。继续扩大和 现代化的会议，组织者正在引入新的倡议，并寻求国家卫生研究院会议 资金支持其实施。 具体目标。我们正在邀请更多的PI，博士后，以及非海胆的研究生 与以前的迭代相比，本次会议的实验室数量有所增加。这些实验室中的许多都使用水生模型来研究人类 疾病与NIH资助的研究计划（例如NIGMS，NIEHS，NINDS和NICHD）。到 强调海洋无脊椎动物研究对了解人类疾病机制的重要性， 我们将继续举办一个专门的全体会议“人类疾病的水生模型”， DBSUMI第二十七次会议。此外，我们将继续举办非常成功的会前研讨会， 由尖端技术专家指导，这些技术最初是在其他模型中开发的 系统，并需要调整适用于海洋无脊椎动物。这些研讨会是一个 会议的重要方面，因为目前没有其他论坛，实验室主要工作 海洋无脊椎动物的专家可以分享他们的技术专长。DBSUMI一直致力于 年轻科学家的职业生涯，但这是第一次，我们正在安排“闪电会谈”，以及 午餐时间的职业表主题这些活动旨在增加年轻科学家的参与 同时鼓励与资深科学家建立网络。最后，我们正在促进一个 全体会议由发言人组成，他们是如何增加统一记录管理多样性的专家， 残疾人。 过去的会议已经获得了NSF，发育生物学学会（SDB）的资助。 和供应商，主要支持学生和博士后参加。今年，我们将寻求资金 来自NIH（NICHD、NIAID、NIEHS和ORIP），用于支付专门设计的倡议的费用 培养学员的社区意识，并让更多的人参加会议。 我们要求1）30名研讨会参与者额外住宿一晚的食宿费，2） 为讲习班租用活动场地，3）提供资金支持提供虚拟出席选项， 4)为学生和博士后提供旅行奖励。

Meeting Rationale. In October 2023, the international community of who use marine invertebrates as research models to address fundamental questions in developmental, cell, ecological, and evolutionary biology will meet for The Developmental Biology of the Sea Urchin and other Marine Invertebrates (DBSUMI). This will be the 27th forum for this meeting, which has been held approximately every 18 months since 1980. Throughout the years, these meetings featured topics relevant to a broad range of biologists working on subjects ranging from gamete interactions, egg activation, cell fate determination and patterning, axis specification, gene expression, genomics, morphogenesis, cell signaling, evolution, ecology, immunology, neurogenesis, regeneration and experimental technology. Importantly, advances in these fields apply not only to sea urchins but more broadly across biological systems. To facilitate these broad findings, the original “sea urchin community” has intentionally expanded the field by inviting researchers working on the cell and developmental biology of other marine invertebrate models including tunicates, hemichordates, cephalochordates, molluscs, polychaetes, cnidarians, ctenophores, and sponges. Each model has its own unique ability to answer fundamental questions that can solve questions related to human development, health and disease. The conceptual basis of comparative studies lies in their ability to identify commonalities of mechanisms and processes across multiple taxa, which in turn reveal unifying principles of biology. Famous examples for major discoveries arising from studies in marine organisms include our knowledge of cell divisions and cyclins, and the role of microtubule motor kinesins, and the development of GFP and other fluorescent proteins as widely-used tools in biomedical science. Thus, our goal is to establish DBSUMI as the “must attend” conference for labs using marine invertebrate model systems to answer a broad range of questions that are highly relevant to human development and health. One central focus of the program is to facilitate in-depth discussions among scientists. The combination of talks, discussion periods, and informal social gatherings allow the integration of findings from diverse systems. DBSUMI XXVII and its future iterations will be indispensable for the growth and vitality of this scientific community, as unique comparative approach across a wide range of marine invertebrate models is underrepresented at any cell, evolutionary and/or developmental biology meetings. To continue expanding and modernizing the meeting, the organizers are introducing new initiatives and seeking NIH meeting funding to support their implementation. Specific Objectives. We are inviting more PIs, post-docs, and graduate students from non-sea urchin labs to this meeting than in previous iterations. Many of these labs use aquatic models for human disease with NIH-funded research programs (e.g. within NIGMS, NIEHS, NINDS, and NICHD). To highlight the relevance of marine invertebrate research for understanding human disease mechanisms, we are continuing to hold a dedicated plenary session “Aquatic Models for Human Disease” in the DBSUMI XXVII meeting. Additionally, we will continue the highly successful pre-meeting workshops directed by experts on cutting-edge technologies that have be originally developed in other model systems and require tweaking to be applicable in marine invertebrates. These workshops are an essential aspect of the meeting because there is currently no other forum where labs primarily working on marine invertebrates can share their technical expertise. DBSUMI has consistently promoted the careers of junior scientists, but for the first time, we are scheduling “lightning talks”, as well as lunchtime career table themes. These events are designed to increase participation of junior scientists while at the same time encouraging network building with senior scientists. Finally, we are promoting a plenary session made up of speakers who are experts on ways to increase the diversity of URM and persons with disabilities. Past meetings have secured funding from the NSF, Society for Developmental Biology (SDB) and vendors to support primarily students and postdocs to attend. This year we are seeking funding from the NIH (NICHD, NIAID, NIEHS and ORIP) to defray the cost of initiatives designed specifically to foster a sense of community among trainees and make the meeting available to a wider community. We are requesting funds for 1) room and board for an extra night’s stay for 30 workshop participants, 2) event space rental for the workshops, 3) funding to support providing a virtual attendance option and 4) travel awards for students and postdocs.