Developmental Biology of the Sea Urchin and Marine Invertebrates (DBSUMI) Meeting XXVII

会议的基本原理。2023年10月，世界卫生组织使用海洋无脊椎动物 作为研究模型，解决发育、细胞、生态和 进化生物学将与海胆和其他海洋的发育生物学相遇 无脊椎动物(DBSUMI)。这将是已经举行的第27届会议论坛 自1980年以来，大约每18个月一次。多年来，这些会议的主题都是 与广泛从事配子相互作用、卵子等主题的生物学家有关 激活、细胞命运决定和构图、轴指定、基因表达、基因组学、 形态发生、细胞信号、进化、生态学、免疫学、神经发生、再生和 实验技术。 重要的是，这些领域的进展不仅适用于海胆，而且适用于更广泛的范围。 生物系统。为了促进这些广泛的发现，最初的“海胆群落” 故意通过邀请从事细胞和发育生物学研究的研究人员来扩大这一领域 其他海洋无脊椎动物模型，包括被毛类、半角类、头颈类、软体动物、 多毛类、线虫、鞭毛虫和海绵动物。每种型号都有自己独特的回答能力 能够解决与人类发展、健康和疾病有关的问题的基本问题。这个 比较研究的概念基础在于它们识别机制的共性的能力 以及跨越多个分类群的过程，这反过来揭示了生物学的统一原则。名扬四海 海洋生物研究产生的重大发现的例子包括我们对细胞的知识 分裂和周期蛋白，微管运动蛋白的作用，以及GFP和GFP的发展 其他荧光蛋白作为生物医学科学中广泛使用的工具。 因此，我们的目标是将DBSUMI确立为实验室“必须出席”的会议 使用海洋无脊椎动物模型系统回答一系列问题 与人类发展和健康高度相关。该计划的一个核心重点是 促进科学家之间的深入讨论。演讲、讨论时段和 非正式的社交聚会允许整合来自不同系统的调查结果。DBSUMI XXVII和 它未来的迭代对于这个科学界的增长和活力将是不可或缺的，因为 广泛的海洋无脊椎动物模型的独特比较方法在 任何细胞、进化和/或发育生物学会议。继续扩张和 为了使会议现代化，组织者提出了新的倡议，并寻求召开NIH会议 为支持它们的实施提供资金。 具体目标。我们正在邀请更多来自非海胆的PI、博士后和研究生 这次会议的实验室比以前的迭代中更多。这些实验室中的许多都使用人类的水生模型 NIH资助的研究项目(例如，在NIGMS、NIEHS、NINDS和NICHD内)。至 强调海洋无脊椎动物研究对了解人类疾病机制的相关性， 我们将继续在北京举行题为“人类疾病的水生模型”的全体会议。 DBSUMI第二十七次会议。此外，我们将继续举办非常成功的会前研讨会。 由最初在其他模式下开发的尖端技术专家指导 系统，并要求微调适用于海洋无脊椎动物。这些研讨会是 会议的基本方面，因为目前没有其他论坛让实验室主要工作 海洋上的无脊椎动物可以分享他们的技术专长。DBSUMI一直在推动 初级科学家的职业生涯，但我们第一次安排了“闪电演讲”，以及 午餐时间职业表主题。这些活动旨在增加初级科学家的参与 同时鼓励与资深科学家建立网络。最后，我们正在推动一个 全体会议由发言者组成，他们是增加城市轨道交通多样性的专家，并 残疾人。 过去的会议已经获得了NSF，发育生物学学会(SDB)的资助 供应商主要支持学生和博士后参加。今年我们正在寻求资金 从NIH(NICHD、NIAID、NIEHS和ORIP)支付专门设计的倡议的成本 在学员中培养社区意识，并使更广泛的社区能够参加会议。 我们要求提供资金，以便1)为30名研修班学员提供额外的食宿，2) 为研讨会租用活动场地，3)提供资金支持提供虚拟出席选项和 4)为学生和博士后提供旅行奖励。

Meeting Rationale. In October 2023, the international community of who use marine invertebrates as research models to address fundamental questions in developmental, cell, ecological, and evolutionary biology will meet for The Developmental Biology of the Sea Urchin and other Marine Invertebrates (DBSUMI). This will be the 27th forum for this meeting, which has been held approximately every 18 months since 1980. Throughout the years, these meetings featured topics relevant to a broad range of biologists working on subjects ranging from gamete interactions, egg activation, cell fate determination and patterning, axis specification, gene expression, genomics, morphogenesis, cell signaling, evolution, ecology, immunology, neurogenesis, regeneration and experimental technology. Importantly, advances in these fields apply not only to sea urchins but more broadly across biological systems. To facilitate these broad findings, the original “sea urchin community” has intentionally expanded the field by inviting researchers working on the cell and developmental biology of other marine invertebrate models including tunicates, hemichordates, cephalochordates, molluscs, polychaetes, cnidarians, ctenophores, and sponges. Each model has its own unique ability to answer fundamental questions that can solve questions related to human development, health and disease. The conceptual basis of comparative studies lies in their ability to identify commonalities of mechanisms and processes across multiple taxa, which in turn reveal unifying principles of biology. Famous examples for major discoveries arising from studies in marine organisms include our knowledge of cell divisions and cyclins, and the role of microtubule motor kinesins, and the development of GFP and other fluorescent proteins as widely-used tools in biomedical science. Thus, our goal is to establish DBSUMI as the “must attend” conference for labs using marine invertebrate model systems to answer a broad range of questions that are highly relevant to human development and health. One central focus of the program is to facilitate in-depth discussions among scientists. The combination of talks, discussion periods, and informal social gatherings allow the integration of findings from diverse systems. DBSUMI XXVII and its future iterations will be indispensable for the growth and vitality of this scientific community, as unique comparative approach across a wide range of marine invertebrate models is underrepresented at any cell, evolutionary and/or developmental biology meetings. To continue expanding and modernizing the meeting, the organizers are introducing new initiatives and seeking NIH meeting funding to support their implementation. Specific Objectives. We are inviting more PIs, post-docs, and graduate students from non-sea urchin labs to this meeting than in previous iterations. Many of these labs use aquatic models for human disease with NIH-funded research programs (e.g. within NIGMS, NIEHS, NINDS, and NICHD). To highlight the relevance of marine invertebrate research for understanding human disease mechanisms, we are continuing to hold a dedicated plenary session “Aquatic Models for Human Disease” in the DBSUMI XXVII meeting. Additionally, we will continue the highly successful pre-meeting workshops directed by experts on cutting-edge technologies that have be originally developed in other model systems and require tweaking to be applicable in marine invertebrates. These workshops are an essential aspect of the meeting because there is currently no other forum where labs primarily working on marine invertebrates can share their technical expertise. DBSUMI has consistently promoted the careers of junior scientists, but for the first time, we are scheduling “lightning talks”, as well as lunchtime career table themes. These events are designed to increase participation of junior scientists while at the same time encouraging network building with senior scientists. Finally, we are promoting a plenary session made up of speakers who are experts on ways to increase the diversity of URM and persons with disabilities. Past meetings have secured funding from the NSF, Society for Developmental Biology (SDB) and vendors to support primarily students and postdocs to attend. This year we are seeking funding from the NIH (NICHD, NIAID, NIEHS and ORIP) to defray the cost of initiatives designed specifically to foster a sense of community among trainees and make the meeting available to a wider community. We are requesting funds for 1) room and board for an extra night’s stay for 30 workshop participants, 2) event space rental for the workshops, 3) funding to support providing a virtual attendance option and 4) travel awards for students and postdocs.