INEXPENSIVE HIGH RESOLUTION PET DETECTOR DEVELOPMENT

该项目的长期目标是改善成像和 正电子相机(PET)的经济性能，使其性能 对器官功能和化学成像可以得到更广泛的应用。这个 PET的检测系统决定了其图像质量和成本。这 该提案旨在为PET开发一种新的探测器设计概念 服务于这些目标。该项目将(A)评估潜力和 意想不到的困难学习基本特征：闪烁 分布和控制它的新技术，光学 特性，晶间康普顿相互作用串扰，以及 符合时间分辨率，(B)开发使用新的原型探测器 实现终极空间分辨率的光控技术 可能并测试原型的性能特征，以及 (C)开发新的计数率增强电路，并将其集成到 防止/纠正检测信号堆积的原型检测系统 在高计数器速率情况下，从而增强计数器速率能力 所提议的探测器的。该算法/电路也应该是可用的 在标准伽马和PET相机中以增强其计数速率能力， 尤其适用于大剂量0-15、Rb-82和单抗成像。二 将研究探测器概念的实现：(1)高 决议。低成本实施，这可能会降低 2,400,000美元的PET价格到1,400,000美元，同时通过 使用与大多数商业PET相同大小的探测器(6.5×6.5 mm)， (2)非常高的分辨率实现，显著提高了 通过将探测器尺寸从6.5x6.5 mm减小到 2.6x2.6 mm，因此探测器的数量增加了6倍，而 有可能将PET的价格降低25%。

The long term objectives of this project are to improve the imaging and economic performance of positron cameras (PET) so that their capability to image organ function and chemistry can be more widely applied. The detection system of a PET dictates its image quality and cost. This proposal aims at developing a new detector design concept for PET to serve these objectives. This project will (a) evaluate potential and unforeseen difficulties study basic characteristics: scintillation distribution and new techniques for controlling it, optical characteristics, inter-crystal Compton interaction cross-talk, and coincidence timing resolution, (b) develop prototype detectors using new light controlling techniques to achieve the ultimate spatial resolution possible and test the performance characteristics of the prototypes, and (c) develop a new count-rate enhancing circuit and integrate it into the prototype detection system to prevent/correct for detection signal pileup in high count-rate situations thus enhancing the count-rate capability of the proposed detector. This algorithm/circuit should also be usable in standard gamma and PET cameras to enhance their count rate capability, especially for high dose 0-15, Rb-82 and monoclonal antibody imaging. Two implementations of the detector concept will be investigated: (1) a high resolution. low cost implementation which may potentially decrease the $2,400,000 PET price to $1,400,000 while maintaining high resolution by using the same size detectors (6.5x6.5mm) as most current commercial PET, (2) a very high resolution implementation which significantly improves image resolution by decreasing the detector size from 6.5x6.5mm to 2.6x2.6mm, thus increasing the number of detectors by six times while potentially lowering the price of PET by 25%.