MOLECULAR EPIDEMIOLOGY OF PROSTATE CANCER

这项提议的目标是调查各种潜在的 可能增加或降低患前列腺癌风险的因素 癌症，一种病因鲜为人知的疾病。的协会 前列腺癌与潜在致癌暴露(有机氯 化合物、镉和锌)、易感因子(GSTM1基因)和 其他风险和/或保护因素(内源性激素、微量营养素、 脂肪酸)将采用嵌套病例对照方法进行前瞻性检查 研究设计。 这项研究将使用1974年收集的诊断前血清进行 以及马里兰州华盛顿县的血浆。血清和血浆将 检测有机氯化合物、锌、镉、硒、视黄醇、 类胡萝卜素、生育酚、抗坏血酸、总抗氧化活性、脂肪 酸、内源激素和GSTMI基因分型将使用Buffy进行 1989年收集的大衣。据估计，有424名男性患有前列腺癌 献血后的癌症将与年龄匹配的对照组进行比较 在诊断病例时，性别和无其他癌症。 这些因素对前列腺癌风险的独立和调节作用 将对癌症进行检查。 从病因学的角度来看，这些发现将有助于理解 环境有机氯化合物暴露的贡献，镉 而锌暴露与前列腺癌的发生和潜在性 遗传性对这些化合物的影响的敏感性。从 预防观点、抗氧化剂和脂肪的修饰作用 有机氯化合物与前列腺酸的关系 癌症值得特别关注，因为这些因素是 服从于实际的预防措施。

The objective of this proposal is to investigate a variety of potential factors that may increase or decrease the risk of developing prostate cancer, a disease whose etiology is poorly understood. Associations of prostate cancer with potential carcinogenic exposures (organochlorine compounds, cadmium and zinc), a susceptibility factor (GSTM1 genotype) and other risk and/or protective factors (endogenous hormones, micronutrients, fatty acids) will be examined prospectively using a nested case-control study design. The study will be conducted using prediagnostic serum collected in 1974 and plasma from 1989 in Washington County Maryland. Serum and plasma will be assayed for organochlorine compounds, zinc, cadmium, selenium, retinol, carotenoids, tocopherols, ascorbic acid, total antioxidant activity, fatty acids, endogenous hormones and GSTMI genotyping will be done using buffy coats collected in 1989. An estimated 424 men who have developed prostate cancer after donating blood will be compared with controls matched on age and gender and free of other cancers at the time of diagnosis of the case. Independent and modifying effects of these factors on the risk of prostate cancer will be examined. From the viewpoint of etiology, findings will aid in understanding the contribution of environmental organochlorine compound exposure, cadmium and zinc exposure to the development of prostate cancer and the potential inherited susceptibility to the effects of these compounds. From the viewpoint of prevention, the modifying effects of antioxidants and fatty acids on the association between organochlorine compounds and prostate cancer deserve particular attention since these are factors that are amenable to practical preventive measures.