IDIOPATHIC INTRAUTERINE GROWTH RETARDATION EPIDEMIOLOGY

描述：(改编自《调查者摘要》)胎儿宫内生长 胎儿发育迟缓(IUGR)是围产儿死亡和发病的主要原因 这可能是可以预防和干预的。然而， 约40%的IUGR没有明显的原因。打造战略基础 在预防方面，有必要做出更多努力来确定以下风险因素 特发性宫内发育迟缓。这项研究旨在确定以下风险因素/预测因素 特发性宫内发育迟缓及其亚型(对称型和非对称型) 衣原体感染与母血甲胎蛋白的关系。此外, 这项研究将超越传统的定义 参考IUGR(第10个百分位数)的出生体重与胎龄 胎儿生长的对称性(庞得拉指数)，它将更好地探索 种族特定的对称性和非对称性IUGR的定义，包括 临床和人体测量。发病率的种族差异 IUGR的比率、模式以及新生儿死亡率和发病率将是 比较并调查特定种族的风险因素。此项目的数据 是从卫生部的产科和新生儿数据库中得出的 产科、妇科和生殖科学系 纽约西奈山医疗中心的儿科，大约有 40,000名不同种族和社会经济背景的孕妇和1000多名 每对母婴的变量。 本研究的具体目的如下。(1)定义IUGR和对称性 胎儿生长发育与出生体重、冠跟长度、头部的关系 周长、胎龄和围产儿死亡率。(2)比较 对称性和非对称性宫内发育迟缓在亚洲人群中的分布和发生率， 黑人、西班牙裔和白人。(3)检查新生儿发病率和 与对称性和非对称性宫内发育迟缓和种族相关的死亡率 不同之处。(4)确定特发性对称性的危险因素/预测因素 不同民族胎儿宫内发育不对称性。(五)检视社团 妊娠期间衣原体感染与特发性宫内发育迟缓之间的关系 母血甲胎蛋白与特发性胎儿宫内发育迟缓的关系(6)最后， 将基于IUGR和对称性的新定义的结果与 基于第10个百分位数和重量指数的数据。

DESCRIPTION: (Adapted from Investigator's Abstract) Intrauterine growth retardation (IUGR) is a major cause of perinatal mortality and morbidity which may be amenable to prevention and intervention. However, approximately 40% of IUGR has no obvious cause. To create a strategic basis for prevention, more efforts are warranted to identify risk factors for idiopathic IUGR. This study aims to identify risk factors/predictors for idiopathic IUGR and subtypes (symmetric and asymmetric) with special focus on chlamydia infection and maternal serum alpha-fetoprotein. In addition, this study will go beyond the conventional definitions of birth-weight-for-gestational-age referenced IUGR (the 10th percentile) and symmetry of fetal growth (Ponderal index), and it will explore better race-specific definitions of symmetric and asymmetric IUGR, incorporating clinical and anthropometric measurements. Racial differences in incidence rates, patterns of IUGR, and neonatal mortality and morbidity will be compared and race-specific risk factors investigated. Data for this project are derived from the obstetric and neonatal databases in the Department of Obstetrics, Gynecology and Reproductive Sciences, and the Department of Pediatrics in the Mount Sinai Medical Center in New York, with approximately 40,000 ethnically and socioeconomically diverse pregnancies and over 1000 variables for each mother-neonate pair. The specific aims of the study are as follow. (1) Define IUGR and symmetry of fetal growth incorporating birth weight, crown-heel length, head circumference, gestational age, and perinatal mortality. (2) Compare the distribution and incidence rates of symmetric and asymmetric IUGR in Asians, blacks, Hispanics and whites. (3) Examine the neonatal morbidity and mortality in relation to symmetric and asymmetric IUGR, and the racial differences. (4) Identify risk factors/predictors for idiopathic symmetry and asymmetry IUGR in different ethnic groups. (5) Examine the associations between chlamydia infection during pregnancy and idiopathic IUGR, and between maternal serum alpha-fetoprotein and idiopathic IUGR. (6) Finally, compare the results based on the new definitions of IUGR and symmetry with those based on 10th percentile and ponderal index.