Project: Survivorship Care Physical Activity Initiative to Improve Disparities in HRQoL for Prostate Cancer Survivors (RELate Study)

完整的研究项目1：生存护理身体活动倡议，以减少HRQOL的差异 前列腺癌的治疗方法 总结 前列腺癌（PCa）治疗的晚期效应可能导致独特的身体和心理社会问题， 长期健康相关生活质量（HRQOL）。增加体力活动（PA）是一种可改变的 可能针对PCa生存相关治疗结局和生活方式的风险因素 行为。PA增加可能对非洲血统（AA）PCa幸存者的结局影响最大， HRQOL和总生存率往往较低，在这些人中，缺乏运动，饮食不良， 肥胖率最高。虽然众所周知，运动可以改善癌症的预后， 幸存者，很少有人知道的生物行为机制和途径，通过它PA可能改善 HRQOL和提高总生存率。晚期糖基化终产物（AGEs）是一种活性代谢产物 在正常代谢以及生物大分子的氧化过程中产生。生活方式因素 如久坐不动的生活方式、不良饮食和肥胖会增加体内的AGE水平。调查人员 假设在一项随机试验中，人类PA/饮食干预与PCa幸存者先前 诊断为I-III期PCa（n=120），较低的AGE水平将与HRQOL改善相关，并将导致 AA和欧美（EA）试验参与者之间免疫应答的差异变化。的 研究人员进一步假设，在小鼠模型干预中，生活方式的机械影响- 与肿瘤相关的免疫应答和肿瘤生长和/或进展将模拟那些 在人体模型中发现。目的1是完成一项为期1年的2组（干预与常规治疗）随机研究， 诊断为I-III期PCa的男性的PA/饮食干预（由M.艾哈迈德，SCSU和D博士。 Turner，MUSC-HCC）。目的二是评估生活方式干预对PA和饮食的影响，并确定其 与AGEs、AGEs前指标和诊断为I-III期PCa的男性HRQOL的关系（由Dr. Ahmed，SCSU）。目的3是使用自发性PCa生活方式小鼠模型来确定AGE-1在PCa中的作用。 信号传导到免疫细胞表型和肿瘤进展（由Turner博士领导，MUSC-HCC）。结果 可能导致药理学和生活方式调整的创新见解，并可以识别保护性 这些因素可能是AA和EA男性之间观察到的PCa治疗结果差异的基础。这 项目是协同相关的其他研究项目包括在此申请

Full Research Project 1: Survivorship Care Physical Activity Initiative to Reduce Disparities in HRQOL for Prostate Cancer Survivors (RELate Study) SUMMARY The late effects of prostate cancer (PCa) treatment can lead to unique physical and psychosocial issues that impact their long-term health-related quality of life (HRQOL). Increased physical activity (PA) is a modifiable risk factor which may be targeted to address PCa survivorship-related treatment outcomes and lifestyle behaviors. Increased PA may have greatest impact on outcomes for African-ancestry (AA) PCa survivors, who tend to have lower HRQOL and overall survival, and in whom factors such as a lack of exercise, poor diet, and rates of obesity are most prevalent. While it is well-known that exercise can improve prognosis among cancer survivors, little is known about the bio-behavioral mechanisms and pathways through which PA may improve HRQOL and increase overall survival. Advanced glycation endproducts (AGEs) are reactive metabolites produced during normal metabolism as well as the oxidation of biological macromolecules. Lifestyle factors such as a sedentary lifestyle, poor diet, and obesity increase AGE levels in the body. The investigators hypothesize that in a randomized trial of a human PA/dietary intervention with PCa survivors previously diagnosed with Stage I-III PCa (n=120), lower AGE levels will correlate with improved HRQOL, and will lead to differential changes in immune response between AA and European American (EA) trial participants. The investigators further hypothesize that in a mouse model intervention, the mechanistic implications of lifestyle- associated AGEs to tumor-associated immune response and tumor growth and/or progression will mimic those found in human models. Aim 1 is to complete a 1-year, 2-arm (intervention vs usual care) randomized PA/dietary intervention in men diagnosed with stage I-III PCa (co-led by Dr. M. Ahmed, SCSU and Dr. D. Turner, MUSC-HCC). Aim 2 is to evaluate the effect of lifestyle intervention on PA and diet, and define their relationship with AGEs, AGEs pre-cursors, and HRQOL in men diagnosed with stage I-III PCa (led by Dr. Ahmed, SCSU). Aim 3 is to use a spontaneous PCa lifestyle mouse model to define the role of AGE-RAGE signaling to immune-cell phenotypes and tumor progression (led by Dr. Turner, MUSC-HCC). The results could lead to innovative insights for pharmacologic and lifestyle adjustment, and could identify protective factors that may underlie observed differences in PCa treatment outcomes between AA and EA men. This project is synergistically related to the other research projects included in this application