Ageing and latelife health: calories, macronutrients or branched chain amino acids?

老龄化研究的主流教条是，在一生中保持热量摄入的实质性减少将延缓衰老和与年龄相关的疾病（热量限制- CR）。然而，CR并没有区分减少卡路里摄入和特定常量营养素摄入的影响，也不能评估常量营养素平衡的影响。本应用程序旨在解开CR和宏量营养素对小鼠健康寿命和寿命影响的作用。

The prevailing dogma of ageing research has been that a substantive reduction in caloric intake maintained over a lifetime will delay ageing and age-related pathologies (caloric restriction - CR). Yet CR does not differentiate between the effects of reduced intake of calories versus specific macronutrients, nor can it assess the impact of balance of macronutrients. This application seeks to disentangle the role of CR and macronutrients on their effects on healthspan and lifespan in mice.