Ageing and latelife health: calories, macronutrients or branched chain amino acids?

老龄化研究的主流教条一直是，在一生中保持实质性的卡路里摄入量减少将延缓衰老和与年龄相关的病理(卡路里限制-CR)。然而，CR没有区分减少卡路里摄入量和特定常量营养素的影响，也不能评估常量营养素平衡的影响。这项申请试图理清CR和常量营养素对小鼠健康和寿命的影响。

The prevailing dogma of ageing research has been that a substantive reduction in caloric intake maintained over a lifetime will delay ageing and age-related pathologies (caloric restriction - CR). Yet CR does not differentiate between the effects of reduced intake of calories versus specific macronutrients, nor can it assess the impact of balance of macronutrients. This application seeks to disentangle the role of CR and macronutrients on their effects on healthspan and lifespan in mice.