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Disease model design and evaluation

Disease model design and evaluation
疾病模型设计与评估
批准号：
10910768
负责人：
Craig Thomas
金额：
$46.59万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10910768
关键词：
3-DimensionalArchitectureBiopsyCell modelCellsComplexDataDiseaseDisease modelEvaluationGenomicsHeterogeneityHumanManuscriptsMethodologyMethodsModelingMolecularMolecular and Cellular BiologyOrganoidsOutcomePatientsPeer ReviewPharmaceutical PreparationsPhysiologicalPositioning AttributeProteomicsPublishingTechniquesTechnologyTissue ModelTissue SampleTissuescomparativedrug discoveryexperimental studyfacsimileinnovationinsightmetabolomicsmodel designnext generationnovelnovel drug classnovel therapeuticsscreeningsmall moleculethree dimensional cell culturetissue culturetissue/cell culturetranscriptomics

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中文摘要
翻译
我们的团队利用细胞培养和组织培养建模的下一代技术来探索疾病起源，进展和治疗的概念，而无需对患者进行侵入性和毫无根据的实验。我们使用各种组学技术和单细胞方法来表征这些模型。我们已经在同行评议的手稿中发表了我们的结果，并利用所产生的数据进一步扩展我们的化学基因组学方法，以定义治疗复杂疾病的新疗法概念。
英文摘要
Our team has utilized next-generation techniques in cell culture and tissue culture modeling to explore concepts in disease origin, progression, and treatment without invasive and unfounded experiments on patients. We characterize these models using a variety of omics technologies and single cell methods. We have published our results in peer-reviewed manuscripts and utilized the data generated to further expand our chemogenomics methods for defining new therapy concepts to treat complex diseases.
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Development of a novel aIIbB3 receptor antagonist for pre-hospital myocardial infarction therapy
Development of a first-in-class O-GlcNAc transferase (OGT) inhibitor
Novel small molecule library development
The development of multikinase inhibitors for the treatment of selected cancers
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