Clinical Research Imaging Core

项目总结/摘要 临床研究成像核心（CRIC）的使命是推进大学的癌症研究 威斯康星州Carbone癌症中心（UWCCC）通过支持准确和有效地使用图像- 基于肿瘤学临床研究的结果衡量标准。审评委通过与经社部合作开展这项工作 1）医学影像研究支持（MIRS），影像研究管理和 放射科的支持部门，2）Radius核心实验室，MIRS内的专用图像分析实验室，以及3） 放射性药物生产设施（RPF）。CRIC提供UWCCC成员和疾病导向 团队（DOT）拥有一个专用的临床研究成像支持中心，该中心与他们的临床 研究，并与他们的研究兴趣和倡议，成功地结合传统和 新型临床肿瘤学成像。目标1：CRIC提供UWCCC临床试验方案成像， 放射性药物可行性审查，以识别和克服研究激活的任何障碍， 实施临床试验工作流程。这包括解决可行性、技术和监管问题 研究激活所需的标准治疗和研究性成像技术的考虑因素，以及 确定适当的肿瘤反应评估成像方法。目标2：审评委与 MIRS用于协调适当的UWCCC癌症特异性临床研究整合和成像 资源使用，并与RPF PET成像的需要。审评委作为沟通联络机构， 将UWCCC临床试验研究需求与MIRS成像工作流程、基础设施和 人员的CRIC确保UWCCC成员和DOT获得研究扫描仪的使用和成像 支持，包括使新的研究成像方法的应用。审评委与 在UWCCC临床试验中纳入临床或试验用PET显像剂的RPF。目标3：审评委 与MIRS Radius核心实验室合作，提供成像肿瘤缓解评估服务， UWCCC临床试验中准确有效的基于图像的结局测量。这种伙伴关系 CRIC和Radius核心实验室之间的合作，由经验丰富的放射科专家进行专家图像分析和审查， 教师UWCCC临床试验与详细的标准化报告，使用标准的CT解剖肿瘤 反应评估和基于PET/CT的评估。目标4：审评委将促进 和扩大新兴的UWCCC治疗诊断临床试验。治疗诊断学涉及使用 用于癌症诊断和治疗的放射性药物。审评委将发挥重要作用， 通过发展中的治疗诊断DOT和剂量测定服务，在UWCCC进行治疗诊断试验。影响：审评委 与放射科的MIRS、MIRS Radius核心实验室和RPF合作， 应用标准护理和创新的新型成像方法，沿着成像专业知识， 推进基于成像的指标，并支持UWCCC的高影响力临床研究。

PROJECT SUMMARY / ABSTRACT The mission of the Clinical Research Imaging Core (CRIC) is to advance cancer research at the University of Wisconsin Carbone Cancer Center (UWCCC) by supporting the accurate and efficient use of image- based outcome measures in oncology clinical research. CRIC does this by partnering with the Department of Radiology’s 1) Medical Imaging Research Support (MIRS), the imaging research administrative and support arm of Radiology, 2) Radius Core Lab, the dedicated image analysis lab within MIRS, and 3) Radiopharmaceutical Production Facility (RPF). CRIC provides UWCCC members and Disease-Oriented Teams (DOTs) with a dedicated clinical research imaging support hub that is integrated with their clinical studies and aligned with their research interests and initiatives to successfully incorporate conventional and novel clinical oncology imaging. Aim 1: CRIC provides UWCCC clinical trial protocol imaging and radiopharmaceutical feasibility review to identify and navigate any obstacles to study activation and clinical trial workflow implementation. This includes addressing feasibility, technical, and regulatory considerations for standard-of-care and investigational imaging techniques needed for study activation, and determining appropriate tumor response assessment imaging methodologies. Aim 2: CRIC partners with MIRS for coordination of proper UWCCC cancer-specific clinical research integration and imaging resource use, and with RPF for PET imaging needs. CRIC serves as the liaison for communication and integration of UWCCC clinical trial research needs with MIRS imaging workflows, infrastructure, and personnel. CRIC ensures UWCCC members and DOTs access to research scanner use and imaging support, including enabling application of novel investigational imaging methods. CRIC coordinates with the RPF for inclusion of clinical or investigational PET imaging agents in UWCCC clinical trials. Aim 3: CRIC partners with MIRS Radius Core Lab to provide imaging tumor response assessment services for accurate and efficient image-based outcome measures in UWCCC clinical trials. This partnership between CRIC and the Radius Core Lab brings expert image analysis and review by experienced radiology faculty to UWCCC clinical trials with detailed standardized reports, using standard CT anatomic tumor response assessments and those that are PET/CT based. Aim 4: CRIC will facilitate the development and expansion of emerging UWCCC theranostic clinical trials. Theranostics involves the use of radiopharmaceuticals for cancer diagnostics and therapy. CRIC will play a vital role in expanding theranostics trials at UWCCC through a developing Theranostic DOT and dosimetry service. Impact: CRIC in partnership with Radiology’s MIRS, MIRS Radius Core Lab, and RPF ensures efficient and accurate application of standard-of-care and innovative novel imaging methods, along with imaging expertise, to advance imaging-based metrics and support high-impact clinical research at UWCCC.