AEROBIC EXERCISE INTERVENTION IN A MULTIETHNIC SYMPTOMATIC HIV-1 INFECTED SAMPLE

该项目扩展了NIMH资助的行为研究， 艾滋病毒感染者的干预措施 （HIV-1）感染。 这些研究表明，一个温和的计划， 无症状和健康男同性恋者的有氧运动训练， 接受阳性HIV-1诊断，降低自我报告水平， 焦虑、抑郁和无助，同时保持积极应对 战略和社会支持后，血清阳性的消息。 的 目前的5年前瞻性研究将确定是否有类似的好处， 心理健康可以从有氧运动训练中获得，由非洲- 和非西班牙裔美国白人男性和女性，有早期症状的艾滋病毒- 1例感染（世界卫生组织3期;世卫组织，1990年），无论 暴露类别。 到目前为止，还没有实验设计 前瞻性压力管理干预研究， 艾滋病多种族男女画跨接触类别。 这 根据我们在有氧运动训练方面的经验， 在过去五年中，HIV-1血清反应阳性者使用了3- 一个月的健身获取期（1小时15分钟的中度 强度运动和拉伸，每3个监督有氧 每周锻炼一次）和9个月的维持期， 有监督的运动训练。 我们将随机抽取176名男性（88名非洲人 美国人，88名非西班牙裔白色美国人）和88名女性（44名非洲裔美国人）。 美国人，44名非西班牙裔白人美国人） 条件或仅评估控制条件，并将进行 有氧健身、心理社会、精神、泌尿和血液 研究入组、3个月和12个月时的评估。 本研究延伸 以前的工作，通过检查长期干预的影响， 非洲裔和非西班牙裔美国白人男性的情感和行为， 应对艾滋病毒相关症状和压力的妇女。 一个 其他延伸涉及认知行为的使用 预防复发的修改包，以确定 有氧运动训练作为长期治疗的可行性 HIV-1感染。

The proposed project extends our NIMH-funded studies of behavioral interventions for individuals with Human Immunodeficiency Virus-Type 1 (HIV-1) infection. These studies showed that a program of moderate aerobic exercise training for asymptomatic and healthy gay males, prior to receiving a positive HIV-1 diagnosis, lowered self-report levels of anxiety, depression, and helplessness, while maintaining active coping strategies and social support following news of seropositivity. The current 5-year prospective study will determine if similar benefits to mental health can be derived, from aerobic exercise training, by African- and nonHispanic White-American men and women, with early symptomatic HIV- 1 infection (World Health Organization stage-3; WHO, 1990) regardless of exposure category. To date, there have been no experimentally designed prospective stress management intervention studies with symptomatic pre- AIDS multiethnic men and women drawn across exposure category. This intervention, based on our experiences with aerobic exercise training in HIV-1 seropositive individuals over the past five years utilizes a 3- month fitness acquisition period (one hour and 15 minutes of moderate intensity exercise and stretching for each of 3 supervised aerobic exercise sessions per week) and a 9-month maintenance period of similar supervised exercise training. We will randomize 176 men (88 African American, 88 nonHispanic White American) and 88 women (44 African- American, 44 nonHispanic White-American) to either the intervention condition or an assessment-only control condition and will conduct aerobic fitness, psychosocial, psychiatric, urinary, and blood assessments at study entry, 3-months, and 12-months. This study extends previous work by examining the effects of a long term intervention on affect and behavior in African- and nonHispanic White-American men and women who are coping with HIV-related symptoms and stressors. An additional extension concerns the use of cognitive behavioral modification package for relapse prevention in order to determine the feasibility of aerobic exercise training as a long-term treatment for HIV-1 infection.