INTRAVASCULAR GELS FOR MODULATION OF ARTERIAL HEALING

描述：(改编自申请者的摘要)建议的作品 使用一种新技术(1)研究治愈的基本生物学 球囊血管成形术中动脉壁损伤和(2)穴位 抑制内膜的新介入治疗的方向 增生和再狭窄。在项目的第一部分，封锁 将用于研究血管内膜形成的机制。 变厚了。血栓预防和血栓的通透性 诱导障碍将不同，以系统地研究其作用 循环和血栓生成因子以一种干净的方式。在 下一部分的工作，蛋白质的释放特性 将对堵塞凝胶进行调查，并将凝胶用于局部 通过释放凝血酶和PDGF来扰乱愈合，这是已知的 影响愈合过程。最后，内皮细胞黏附- 促进肽将被结合到可降解的凝胶中以 开发一种材料，可以促进损伤的再内皮化 地点。

DESCRIPTION: (Adapted from the applicant's abstract) The proposed work uses a novel technique to (1) investigate the basic biology of healing in balloon-angioplasty injury of arterial wall and (2) point the direction to new interventional therapies which will inhibit intimal hyperplasia and restenosis. In the first part of the project, blockade of platelet deposition will be used to investigate mechanisms of intimal thickening. The permeability of both thrombus-preventing and thrombus- inducing barriers will be varied to systematically investigate the role of circulating and thrombus-generated factors in a clean fashion. In the next part of the work, the protein release characteristics of the blockading gels will be investigated and the gels will be used to locally perturb healing by release of thrombin and PDGF, which are known to influence the healing process. Finally, endothelial-cell adhesion- promoting peptides will be incorporporated into degradable gels to develop a material which will enhance re-endothelialization of the injury site.