CLINICAL ONCOLOGY RESEARCH CAREER DEVELOPMENT PROGRAM

描述(申请人的描述)：基础研究导致了专业 在了解一些癌症的基本生物学方面取得的突破 对小说鉴定方面的进步做出了重大贡献 专门针对肿瘤细胞的治疗策略。最大的 改善癌症患者预后的挑战在于 将这些科学突破转化为临床可测试的能力 假设与明确可实现的临床试验设计 终端。翻译实验室发现的一个关键要素 临床概念是临床研究人员的可用性，他们是 在基础科学和临床研究方面训练有素，流利。这个 UAB临床肿瘤学研究职业发展计划的目标是 鼓励招募和培训基础科学领域的年轻肿瘤学家 和临床研究。最终目的是为了发展临床 能够弥合基础科学和科学之间鸿沟的研究人员 临床研究，并活跃在翻译研究领域。 候选人将从UAB内的所有肿瘤学专业招募 癌症中心等学术机构。候选人将被指派 到他们选择的基础科学领域，并接受“动手”和说教 基础研究培训(第一阶段)，然后是临床培训 调查(第二阶段)和向独立职业生涯的过渡 以患者为中心的临床研究(第三阶段)。该项目将是一个联合项目 基础科学家和临床研究人员在癌症领域的努力 中心和候选人将由一群经验丰富和 全国知名的调查人员。在过去的四年里，在九个国家中 已经参加了UAB临床研究员培训计划的研究员， 其中六人在三个不同的肿瘤学领域从事学术生涯 特色菜。这些候选人已经成功地竞争了外部 资金，并且已经开发或正在开发 独立从事临床研究。提议的计划建立 在这一成功的基础上，又得到了加强，加强了临床 调查和翻译研究部分。

DESCRIPTION (Applicant's Description): Basic research has led to major breakthroughs in understanding the basic biology of a number of cancers as well as contributed substantially to advances in identifying novel therapeutic strategies specifically targeting tumor cells. The biggest challenge to improving the outcome of patients with cancer lies in the ability to translate these scientific breakthroughs into clinically testable hypothesis and the design of clinical trials with defined and achievable endpoints. A key requisite in the translation of laboratory discoveries into clinical concepts is the availability of clinical investigators who are trained and fluent in both the basic sciences and clinical research. The goal of the UAB Clinical Oncology Research Career Development Program is to stimulate the recruitment and training of young oncologists in basic science and clinical research. The ultimate aim is to develop clinical investigators who are able to "bridge the gap" between basic science and clinical research and are active in the area of translational investigation. Candidates will be recruited from all oncology specialties within the UAB Cancer Center and other academic institutions. Candidates will be assigned to a basic science area of their choice and receive "hands on" and didactic training in basic research (Phase I), followed by training in clinical investigation (Phase II) and transition to independent careers in patient-oriented clinical research (Phase III). The program will be a joint effort of basic scientists and clinical investigators within the Cancer Center and candidates will be trained by a faculty of experienced and nationally known investigators. Over the past four years, of the nine fellows that have entered the clinical investigator training program at UAB, six have gone on to undertake academic careers in three different oncologic specialties. These candidates have competed successfully for external funding and have developed or are in the process of developing an independent career in clinical investigation. The proposed program builds on this success and has been enhanced to strengthen the clinical investigation and translational research components.