Novel regulators of glucose metabolism and inflammation in adipose tissue of females

肥胖是一个常见的问题，可能会导致糖尿病和心脏病的发展。肥胖导致这些疾病的主要机制之一涉及胰岛素刺激细胞摄取葡萄糖的能力缺陷。我们发现，女性体内过多的性激素睾丸素会导致组织中的这一缺陷。这项研究将调查为什么睾丸激素会导致女性的这种缺陷，以及是否可以使用现有的药物疗法来预防这种缺陷。

Obesity is a common problem which can lead to development of diabetes and heart disease. One of the major mechanisms by which obesity leads to these diseases involves a defect in the ability of insulin to stimulate uptake of glucose into cells. We have found that excess of the sex hormone testosterone in women can contribute to this defect in tissues. This study will investigate why testosterone causes this defect in females and whether this defect can be prevented using existing drug therapies.