ANTERIOR TEMPORAL LOBECTOMY: COMPARISON OF TWO SURGICAL

这项拨款建议对癫痫发作进行前瞻性的纵向研究， 前路手术的精神病学、神经心理学和职业结局 颞叶切除术治疗复杂部分性癫痫 起源于颞叶。ATL将由一个外科团队完成，但 患者将被随机分成两个手术组。一组患者 将通过标准的“整块”切除来完成ATL。另一位病人 各组将有复杂的部分性癫痫发作，发作期为近侧发作 并且将不会具有因果结构损害(即， 肿瘤或动静脉畸形)经MRI扫描证实。研究结果将：(1)有助于 阐明海马体在非损伤性颞叶癫痫中的作用 (2)帮助澄清几种ATL方法中哪种方法产生的效果最好 癫痫发作结局与最小的心理和精神损害 病人。这项建议直接适用于最近的 美国国立卫生研究院癫痫手术共识会议。

This grant proposes a prospective longitudinal study of the seizure, psychiatric, neuropsychological, and vocational outcome of anterior temporal lobectomy (ATL) done for treatment of complex partial seizures of temporal lobe origin. ATL will be done by one surgical team but the patients will be randomized into two surgical groups. One patient group will have ATL done by a standard "en bloc" resection. The other patient groups will have complex partial seizures with ictal onset from mesial temporal structures and will not have a causal structural lesion (i.e., tumor or AVM) documented by MRI scan. The outcome of study will: (1) help clarify the role of hippocampus in nonlesional temporal lobe epilepsy, and (2) help clarify the which of several methods of ATL produce the best seizure outcome with minimal psychological and psychiatric impairment to patients. This proposal apples directly to the conclusion of the recent NIH consensus conference of Epilepsy Surgery.