Novel strategy to reduce renal fibrosis

肾纤维化是糖尿病患者的一种严重并发症。这一过程主要由转化生长因子（tgf - β）控制。然而，由于其其他重要功能，直接靶向tgf - β作为治疗方法是不合适的。我们的初步数据表明，细胞分裂自身抗原1 （CDA1）对tgf - β的致病活性至关重要。我们建议使用我们最近产生的独特的CDA1基因敲除小鼠来证明CDA1的重要作用。

Kidney fibrosis is a serious complication seen in diabetic subjects. This process is mainly controlled by transforming growth factor beta (TGF-beta). However, direct targeting of TGF-beta as a therapeutic approach is inappropriate due to its other important functions. Our preliminary data show that Cell Division Autoantigen 1 (CDA1) is critical for the disease causing activity of TGF-beta. We propose to use our recently generated unique CDA1 gene knockout mouse to demonstrate this important role of CDA1.