Immunobiology of Influenza Virus Infection: Vaccinating against an evolving virus

性状（由申请人提供）：流感病毒是一种不断变化的病毒。定期突变和选择或抗原漂移导致免疫力丧失，需要定期重新配制每年的人流感疫苗。流感病毒也通过选择性压力发生变化，并在本质上对抗病毒药物产生耐药性。与此同时，流感病毒正在改变宿主。禽流感病毒已感染多种猫科动物，马流感病毒似乎已在犬科动物中建立。最重要的是，H5 N1禽流感似乎准备改变物种，并可能导致下一次大流行。基础和应用研究的最新进展为了解病毒、宿主和免疫系统之间的相互作用提供了前所未有的机会，特别是在病毒进化、病毒生态学、免疫力的产生以及免疫记忆反应的产生和维持机制方面。本次会议将汇集来自学术界、政府和工业界的基础和应用科学家，以促进将基础研究的新发现有效转化为有效的疫苗和疗法。它将汇集进化病毒学家，病毒生态学家，病毒免疫学家和疫苗学家;不经常互动的群体，讨论流感病毒生物学，免疫学和疫苗。它还将为学生和初级科学家提供一个与领先的流感研究人员会面和互动的机会。会议的目标是增加对流感病毒和病毒进化、对病毒的免疫反应以及流感疫苗设计的了解，以改进能够更好地控制这种不断变化的病原体的抗流感药物和疫苗。

DESCRIPTION (provided by applicant): Influenza virus is a constantly changing virus. Regular mutation and selection, or antigenic drift results in loss of immunity and the requirement of regular reformulation of annual human influenza vaccines. Influenza viruses are also changing through selective pressure and in nature to be resistant against anti-viral drugs. At the same time, influenza virus is changing hosts. Avian influenza viruses have infected a variety of feline species and equine influenza virus appears to be established in canine populations. Most importantly, H5N1 avian influenza appears poised to shift species and could cause the next pandemic. Recent advances in basic and applied research provide an unparalleled opportunity to understand the interplay between the virus, the host, and the immune system, particularly on matters of virus evolution, virus ecology, the generation of immunity, and mechanisms involved in the generation and maintenance of immune memory responses. This meeting will assemble basic and applied scientists from academia, government, and industry to foster effective translation of new findings in basic research into effective vaccines and therapies. It will bring together evolutionary virologists, viral ecologists, viral immunologists, and vaccinologists; groups which do not regularly interact, to discuss influenza virus biology, immunology and vaccines. It will also provide an opportunity for students and junior scientists to meet and interact with leading influenza researchers. The goal of the meeting is to increase understanding of influenza virus and virus evolution, immune responses to the virus, and influenza vaccine design in order to improve anti-influenza drugs and vaccines that are better able to control this changing pathogen.