Mobile Elements in Mammalian Genomes

描述：（由申请人提供）：第三届FASEB夏季会议“哺乳动物基因组中的移动元素”将于2009年7月5日至10日在科罗拉多州Snowmass举行，现要求部分支持。会议的目的是将对移动DNA有共同兴趣的不同研究人员聚集在一起，讨论移动元件如何影响并继续影响哺乳动物基因组的功能表达和进化的最新进展。该计划包括移动DNA的所有方面，包括生物信息学、生化、进化和哺乳动物转座因子的群体遗传研究，以及利用转座因子进行饱和诱变和基因传递的工作。比较基因组学为移动DNA在进化过程中的扩增、抑制和灭绝提供了强有力的证据。最近，对小抑制RNA途径的详细研究已经提供了强有力的证据，证明该途径突变体中可移动DNA的抑制；这两个领域的新界面将在本次会议上由一个新的会议来代表。在基因组结构和功能中，对转座因子衍生序列的各种作用进行定义的研究也将增加。这次及时的会议将促进学生、博士后学员和初级和高级主要研究人员在这个快速发展的领域分享令人兴奋的新发现、实验挑战和悬而未决的问题。

DESCRIPTION: (provided by applicant): Partial support is requested for the third FASEB Summer Conference, "Mobile Elements in Mammalian Genomes" which will be held in Snowmass, CO, July 5-10, 2009. The objective of the meeting is to bring together a diverse group of investigators with a common interest in mobile DNA to discuss recent advances in how mobile elements have impacted and continue to influence the functional expression and evolution of mammalian genomes. The program comprises all aspects of mobile DNA including bioinformatics, biochemical, evolutionary, and population genetic studies on mammalian transposable elements, as well as work to exploit transposable elements for saturation mutagenesis and gene delivery. Comparative genomics provides strong evidence for mobile DNA amplification, repression and extinction in evolutionary time. Recently, detailed studies of the small inhibitory RNA pathway have provided strong evidence for derepression of mobile DNA in mutants of this pathway; the emerging interface of these two fields will be represented by a new session at this meeting. There will also be increased representation of studies that define a variety of roles for sequences derived from transposable elements in genome architecture and function. This timely conference will facilitate the sharing of exciting new findings, experimental challenges, and outstanding questions in this rapidly evolving field among students, post-doctoral trainees, and junior and senior principal investigators. PUBLIC HEALTH RELEVANCE: Mobile DNA has played, and continues to play a major role in shaping the structure and function of the mammalian genome. Retrotransposition deposits new copies of mobile DNA throughout the genome which can lead to gene disruption, modified expression of adjacent genes, and transduction of neighboring DNA; at the DNA level the resulting interspersed repeated sequences may give rise to novel regulatory networks, or provide a substrate for homologous recombination of mispaired sequences, leading to gene duplication, deletion, exon shuffling and chromosome translocation. Any one of the dynamic events caused by the presence and movement of mobile DNA in the human genome may lead to disease, including meiotic failure and infertility, inherited genetic diseases such as hemophilia and muscular dystrophy, and somatic diseases such as breast and colon cancer.