Proteases in Hemostasis and Vascular Biology

描述（由申请人提供）： 我们请求对在美国实验生物学学会联合会（FASEB）夏季会议计划的主持下举行的题为“止血和血管生物学中的蛋白酶”的会议提供部分支持。拟议的会议将于2009年6月7日至12日在亚利桑那州无忧无虑的FASEB夏季会议现场举行。这次会议将是自1992年以来每两年举行一次的非常成功的系列会议中的第9次。会议的重点已经从最初致力于凝血酶的结构-功能研究发展到止血和血管生物学中蛋白酶及其受体的更广泛的竞技场。鉴于止血系统和血管细胞信号传导对心血管疾病基础的多重贡献，对该领域的兴趣仍然很强。该会议已在该领域确立了自己的地位，并享有国际声誉，因为它是一个以平衡、非正式和高度互动的方式讨论该问题的基础科学的广泛领域，包括生物技术和医学问题的会议。最近在血栓形成和止血领域取得的一些最引人注目的成就在本系列的前几次会议上首次亮相，或者是由本次会议促进的合作互动所推动的。受邀发言者和已同意参加讨论的领导人名单令人印象深刻，代表了该领域的顶级调查人员。这些与会者将提高所有与会者，特别是初级研究人员和学员的环境的刺激性。与以往的会议一样，我们将奋进促进妇女和少数民族的参与，并促进初级教师、学生、博士后研究员和身体残疾者的出席。该计划目前包括一个主题演讲和9个会议，致力于（1）血小板信号传导，（2）凝血蛋白酶及其抑制剂的生物化学，（3）新型丝氨酸蛋白酶和功能，（4）血栓形成中蛋白酶的调节，（5）纤维蛋白，纤维蛋白溶解和神经生物学中的蛋白酶，（6）蛋白酶的血管信号传导，（7）炎症和宿主防御中的蛋白酶，（8）治疗方面，和（9）新兴技术和蛋白酶工程。(End摘要）

DESCRIPTION (provided by applicant): We request partial support for a conference entitled "Proteases in Hemostasis and Vascular Biology" to be held under the auspices of the Summer Conference program of the Federation of American Societies for Experimental Biology (FASEB). The proposed conference is to be held at the FASEB summer conference site in Carefree, Arizona June 7-12, 2009. This conference will be the 9th such meeting in a highly successful series that has been held biennially since 1992. The focus of the meeting has evolved from one originally devoted to structure-function studies of thrombin into the broader arena of proteases and their receptors in hemostasis and vascular biology. Interest in this area remains strong in view of the multiple contributions of the hemostatic system and vascular cell signaling to the underpinnings of cardiovascular disease. The conference has established itself in the field and enjoys an international reputation for being one in which wide areas of the basic science of the problem including biotechnology and medical issues are discussed in a balanced, informal and highly interactive manner. Some of the most spectacular recent achievements in the area of thrombosis and hemostasis have been first unveiled at previous conferences in this series or have been driven by collaborative interactions fostered by this conference. The roster of invited speakers and discussion leaders who have already agreed to participate is impressive and represents top investigators in the field. These attendees will enhance the stimulating nature of the environment for all attendees and especially junior investigators and trainees. As in past conferences, we will endeavor to promote participation by women and minorities and facilitate attendance by junior faculty, students, postdoctoral fellows and individuals with physical disabilities. The program currently includes a keynote address and 9 sessions devoted to (1) platelet signaling, (2) the biochemistry of coagulation proteases and their inhibitors, (3) novel serine proteases and functions, (4) regulation of proteases in thrombosis, (5) fibrin, fibrinolysis, and proteases in neurobiology, (6) vascular signaling of proteases, (7) proteases in inflammation and host defense, (8) therapeutic aspects, and (9) emerging technologies and protease engineering. (End of Abstract)