2009 Proteins Gordon Conference

项目描述（由申请人提供）：项目摘要申请资金支持2009年蛋白质戈登研究会议。这是一个长期存在且通常超额认购的会议，服务于科学界，专注于蛋白质分子的基本特性，包括它们的结构、折叠、动力学、稳定性和相互作用。作为2007年会议的副主席，Fetrow和Oas参与了Hill和Pielak主席的一个有意识的决定，即在会议和讨论主题中纳入更多的蜂窝焦点。《蛋白质》的更新受到2007年会议参与者的普遍欢迎，我们已经开发了一个程序，继续这一脉络。然而，我们也认识到，为现代蛋白质科学奠定基础的科学家在2007年的参与度比往年要低。为了增加他们的参与，我们制定了一个计划，旨在为年轻的蛋白质科学家提供该领域资深领导者所能提供的见解和观点。这些资深科学家将主持他们的工作对其主题有重大影响的会议。他们将在会议开始或结束时发表演讲，为令人兴奋的蛋白质科学新子领域提供历史背景，并在每次会议结束时引导30分钟的讨论。每次会议的演讲者都包括年轻的科学家，他们的工作重点是蛋白质的生物学背景。通过这种方式，我们将把经典蛋白质科学的最佳成果与该领域的最新研究成果结合起来。在选择2009年会议的主题和演讲者时，我们征求了蛋白质科学界的意见，并纳入了响应2007年计划的建议。现任联合副主席克拉克和鲍伊也积极参与了2009年会议的筹备工作。为了回应对2007年会议的批评，我们正在计划一些措施来增加所有会议参与者之间的互动，特别是高级和初级科学家之间的互动。除了最后的主题会议外，2009年的日程安排还包括以下常规会议：后还原主义蛋白质科学；2. 共溶质和水在蛋白质稳定性中的作用3. Protein-RNA生物学;4. 重述氢键和疏水性；5. 淀粉样蛋白形成理论；6. 蛋白质异质性的功能影响；7. 细胞中的蛋白质功能和配体结合。

DESCRIPTION (provided by applicant): Project abstract Funds are requested to support the 2009 Proteins Gordon Research Conference. This is a long-standing and usually oversubscribed meeting that serves the scientific community and is focused on the fundamental properties of protein molecules, including their structure, folding, dynamics, stability, and interactions. As vice chairs of the 2007 meeting, Fetrow and Oas participated in a conscious decision on the part of chairs Hill and Pielak to incorporate a more cellular focus in the session and talk topics. This updating of Proteins was generally well received by the participants of the 2007 meeting and we have developed a program that continues in this vein. However, we have also recognized that the participation of the scientists who laid the foundation for modern protein science was lower in 2007 than in previous years. To increase their participation, we have developed a program designed to provide younger protein scientists with the insights and perspectives accomplished senior leaders of the field can provide. These senior scientists will chair sessions whose topics their work has significantly impacted. They will present talks at the beginning or end of their session, which will provide historical context to exciting new sub-fields of protein science and lead the 30-minute discussions at the end of each session. Speakers in each session include younger scientists, whose work focuses on proteins in their biological context. In this way, we will bring together the best of classical protein science with the best of the newer research in the field. In choosing topics and speakers for the 2009 meeting, we sought input from the protein science community and have incorporated suggestions offered in response to the 2007 program. The current co-vice chairs, Clark and Bowie, are also heavily involved in planning the 2009 meeting. In response to a criticism of the 2007 meeting, we are planning several measures to increase the interaction between all meeting participants, particularly the senior and junior scientists. In addition to a final keynote session, the 2009 schedule includes the following regular sessions: 1. Post-reductionist protein science; 2. Role of co-solutes and water in protein stability; 3. Protein-RNA biology; 4. The hydrogen bond and hydrophobicity, revisited; 5. Theory of amyloid formation; 6. Functional consequences of protein heterogeneity; 7. Protein function and ligand binding in the cell. Public Health Relevance: Project narrative, including health-related significance Proteins are central actors in most biological processes, including those relevant to human health. Proteins are involved in such important biological processes as signaling pathways, metabolism, and gene expression. They are the usual targets of therapeutic drugs and protein mutation, mis-folding or dysfunction is directly implicated in many diseases. The 2009 Proteins GRC will explore recent advances and future trends in understanding the structure, stability, motions, and interactions of protein molecules and how these fundamental properties impact function in the biological context.