2009 Hormone Action in Development and Cancer Gordon Conference

描述(由申请人提供)：第三届戈登研究会议(GRC)关于激素在发育和癌症中的作用将于2009年7月26-31日在NH普利茅斯的Holderness学校举行。它的设计是将激素行动、发育和癌症生物学这三个截然不同但重叠的领域合并为一个正在进行的会议，该会议将导致在每个领域共同的潜在分子和细胞机制方面的想法和知识的交叉培养。值得注意的是，这次GRC是唯一一个完全融合了所有三个主题的会议，使其独一无二。2009年GRC的中心主题是发育和癌症的荷尔蒙调节：共同的信号通路。它是基于越来越多的人意识到，调节早期生命发育生长和跨器官和门的分化的共同和独特的信号通路也是癌症发展、生长和进展的主要参与者，这导致了癌症作为发育出错的概念。在这一框架内，器官部位特异性致癌以及某些发育过程还受到激素作用的共同机制的额外调节。本次会议将特别关注调节下游信号通路的激素依赖作用，这些信号通路涉及发育和癌症，并突出了目前正在塑造这一研究领域的戏剧性最近的进展。会议将从确定会议主题的主旨演讲开始，随后将在接下来的几天里举行八个主题会议，主要科学家将重点介绍激素作用的新信息，不同类群中发育事件的激素调节，癌症中出错的发育途径，类固醇在乳腺癌和前列腺癌中的作用，不同部位和通过替代途径的激素致癌，环境内分泌干扰物对发育和癌症的影响，激素控制下的发育和癌症的表观基因组学机制，以及翻译研究的新方法。组织这次会议的目的是在整个会议期间整合这些不同的主题，以便进行公开和内容丰富的讨论，介绍新的范例，并引导该领域朝着新的发现迈进。GRC是一个独特的场所，通过在每届会议上广泛讨论的形式促进科学思想的自由交流，充足的自由时间鼓励非正式互动，并在海报会议上进行交流，允许与会者展示他们最新的研究成果--所有这些都是在大学式的氛围中进行的。学员将有多种机会参与，包括海报会议、资助学员旅行奖和在每个上午的会议上介绍青年调查员。会议上的各种研究主题和翻译机会不仅会引起国家癌症研究所(NCI)的兴趣，也会引起国家糖尿病、消化和肾脏疾病研究所(NIDDK)、国家儿童健康与人类发育研究所(NICHD)、国家老龄研究所(NIA)和国家环境健康科学研究所(NIEHS)的兴趣。 公共卫生相关性：这次会议将汇聚癌症生物学、发育生物学和内分泌学领域的基础和翻译科学家和临床医生，以促进这些科学界之间思想和技术的交叉培养。这一交流过程对于开发新的方法和确定未来癌症治疗和化学预防战略的转化机会至关重要。2009年荷尔蒙在发育和癌症中的作用GRC的主要目标是为与会者提供一个论坛，以了解最新进展，在研究领域交流科学思想，并形成新的治疗范例，应用于癌症治疗。

DESCRIPTION (provided by applicant): The third Gordon Research Conference (GRC) on Hormone Action in Development and Cancer will be held July 26-31, 2009 at the Holderness School in Plymouth, NH. It was designed to merge three distinct yet overlapping fields of Hormone Action, Development, and Cancer Biology into one ongoing conference that will lead to cross-fertilization of ideas and knowledge on the underlying molecular and cellular mechanisms common to each field. It is notable that this GRC is only conference that fully integrates all three topics, making it unique. The central theme of the 2009 GRC is Hormonal Regulation of Development and Cancer: Common Signaling Pathways. It is based on the growing awareness that common and unique signaling pathways that regulate early life developmental growth and differentiation across organs and phyla are also major participants in the development, growth and progression of cancers leading to the concept of cancer as development gone awry. Within this framework, organ site-specific carcinogenesis as well as certain developmental processes are additionally regulated by common mechanisms of hormone action. This conference will specifically focus on hormone-dependent actions that regulate down-stream signaling pathways involved in development and cancer and highlight the dramatic recent advances that are currently shaping this field of research. The meeting will commence with Keynote addresses that will establish the conference theme followed by eight topic sessions over the following days with presentations by leading scientists highlighting new information on hormone action, hormonal regulation of developmental events in diverse phyla, developmental pathways gone awry in cancer, steroid action in breast and prostate cancer, hormonal carcinogenesis at various sites and through alternate pathways, effects of environmental endocrine disruptors on development and cancer, epigenomic mechanisms in development and cancer under the control of hormones, and novel approaches for translational research. The conference has been organized to integrate these various topics throughout the meeting to permit open and informative discussions, introduce new paradigms and lead the field forward towards novel discoveries. The GRC represents a unique venue for promoting unfettered interchange of scientific ideas through its format of extensive discussion periods at each session, ample free time to encourage informal interactions, and exchanges at poster sessions that will allow attendees to present their latest research findings- all within a college-like atmosphere. There will be multiple opportunities for trainee participation including poster sessions, funding of Trainee Travel Awards and Young Investigator presentations at each morning session. The diverse research topics and translational opportunities represented at the meeting will be of interest not only to the National Cancer Institute (NCI) but also to the National Institute on Diabetes, Digestive and Kidney Disease (NIDDK), the National Institute of Child Health and Human Development (NICHD), the National Institute on Aging (NIA) and the National Institute on Environmental Health Sciences (NIEHS). Public Health Relevance: This meeting will bring together basic and translational scientists and clinicians in the fields of cancer biology, developmental biology and endocrinology in order to foster cross fertilization of ideas and techniques between these scientific communities. This process of communication is essential for the development of new approaches and the identification of translational opportunities for future cancer treatments and chemopreventive strategies. The primary objective of the 2009 GRC on Hormone Action in Development and Cancer is to provide a forum for attendees to learn about the latest advancements, exchange scientific ideas across research field and form new treatment paradigms for application in cancer therapy.