Development of New Hemostatic Dressings

描述（由申请人提供）：一个多学科研究团队旨在开发用于严重（例如动脉）出血的新型且经济可行的植入式止血敷料。正在开发的器械的主要特征是其出色的柔韧性、生物相容性和纳米/微工程结构，以最大限度地提高性能，而无需过量的促凝血剂。LNKChemsolutions LLC及其学术合作伙伴将在体外进行（例如，血栓弹性描记术）和使用猪模型的体内验证研究，并且最初集中于最可能仅经历适度至合理的调节抗性的绷带制剂。长期目标侧重于与国内和国际合作伙伴建立伙伴关系，利用动物、酵母和/或植物表达平台生产重组凝血因子。公共卫生相关性：该SBIR提案是一项多学科努力，旨在开发用于出血控制的新型植入式敷料，重点是治疗严重动脉出血情况。民用和军用市场都将大大受益于该领域的重要进展。

DESCRIPTION (provided by applicant): A multidisciplinary team of researchers seeks to develop novel and economically feasible implantable hemostatic dressings for severe (e.g. arterial) bleeding. Key features of the device under development are its excellent pliability, biocompatibility, and nano/microengineered structure to maximize performance without requiring excessive amounts of procoagulants. LNKChemsolutions LLC and its academic partners will conduct in vitro (e.g., thromboelastography) and in vivo validation studies using a swine model, and focus initially on bandage formulations that are most likely to experience only modest to reasonable regulatory resistance. Long term goals focus on developing partnerships with national and international partners with animal, yeast and/or plant expression platforms for recombinant clotting factors. PUBLIC HEALTH RELEVANCE: This SBIR proposal is a multidisciplinary effort to develop new implantable dressings for hemorrhage control, with emphasis on treatment of severe arterial bleeding situations. Both the civilian and military markets will greatly benefit from important advances in the field.